Prolonged Myelosuppression due to Progressive Bone Marrow Fibrosis in a Patient with Acute Promyelocytic Leukemia
Joint Authors
Saito, Taku
Inagawa, Yuta
Komeno, Yukiko
Saito, Satoshi
Maenohara, Yuji
Yamagishi, Tetsuro
Kawashima, Hiroyuki
Abe, Keiko
Iihara, Kuniko
Hatada, Yasumasa
Ryu, Tomiko
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-11-27
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
A 34-year-old woman was diagnosed with acute promyelocytic leukemia.
Chemotherapy was administered following the JALSG APL204 protocol.
Induction therapy with all-trans retinoic acid resulted in complete remission on day 49.
She developed coccygeal pain from day 18, which spread to the spine and cheekbones and lasted 5 weeks.
She had similar bone pain on days 7–10 of the first consolidation therapy and on days 4–12 of the second consolidation therapy.
Oral loxoprofen was prescribed for pain relief.
On day 33 of the third consolidation, white blood cell and neutrophil counts were 320/μL and 20/μL, respectively.
After she developed epigastralgia and hematemesis, she developed septic shock.
Gastroendoscopy revealed markedly thickened folds and diffusely damaged mucosa with blood oozing.
Computed tomography revealed thickened walls of the antrum and the pylorus.
Despite emergency treatments, she died.
Bacterial culture of the gastric fluid yielded Enterobacter cloacae and enterococci growth.
Collectively, she was diagnosed with phlegmonous gastritis.
Retrospective examination of serial bone marrow biopsy specimens demonstrated progressive bone marrow fibrosis, which may have caused prolonged myelosuppression.
Thus, evaluation of bone marrow fibrosis by bone marrow biopsy after each treatment cycle might serve as a predictor of persistent myelosuppression induced by chemotherapy.
American Psychological Association (APA)
Inagawa, Yuta& Komeno, Yukiko& Saito, Satoshi& Maenohara, Yuji& Yamagishi, Tetsuro& Kawashima, Hiroyuki…[et al.]. 2019. Prolonged Myelosuppression due to Progressive Bone Marrow Fibrosis in a Patient with Acute Promyelocytic Leukemia. Case Reports in Hematology،Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1136432
Modern Language Association (MLA)
Inagawa, Yuta…[et al.]. Prolonged Myelosuppression due to Progressive Bone Marrow Fibrosis in a Patient with Acute Promyelocytic Leukemia. Case Reports in Hematology No. 2019 (2019), pp.1-7.
https://search.emarefa.net/detail/BIM-1136432
American Medical Association (AMA)
Inagawa, Yuta& Komeno, Yukiko& Saito, Satoshi& Maenohara, Yuji& Yamagishi, Tetsuro& Kawashima, Hiroyuki…[et al.]. Prolonged Myelosuppression due to Progressive Bone Marrow Fibrosis in a Patient with Acute Promyelocytic Leukemia. Case Reports in Hematology. 2019. Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1136432
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1136432