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An Antibacterial Strategy of Mg-Cu Bone Grafting in Infection-Mediated Periodontics
Joint Authors
Pan, Yaping
Zhao, Xue
Wan, Peng
Wang, Hongyan
Zhang, Shuwei
Liu, Jingbo
Chang, Chunrong
Yang, Ke
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-08-28
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Periodontal diseases are mainly the results of infections and inflammation of the gum and bone that surround and support the teeth.
In this study, the alveolar bone destruction in periodontitis is hypothesized to be treated with novel Mg-Cu alloy grafts due to their antimicrobial and osteopromotive properties.
In order to study this new strategy using Mg-Cu alloy grafts as a periodontal bone substitute, the in vitro degradation and antibacterial performance were examined.
The pH variation and Mg2+ and Cu2+ release of Mg-Cu alloy extracts were measured.
Porphyromonas gingivalis (P.
gingivalis) and Aggregatibacter actinomycetemcomitans (A.
actinomycetemcomitans), two common bacteria associated with periodontal disease, were cultured in Mg-Cu alloy extracts, and bacterial survival rate was evaluated.
The changes of bacterial biofilm and its structure were revealed by scanning electron microscopy (SEM) and transmission electronic microscopy (TEM), respectively.
The results showed that the Mg-Cu alloy could significantly decrease the survival rates of both P.
gingivalis and A.
actinomycetemcomitans.
Furthermore, the bacterial biofilms were completely destroyed in Mg-Cu alloy extracts, and the bacterial cell membranes were damaged, finally leading to bacterial apoptosis.
These results indicate that the Mg-Cu alloy can effectively eliminate periodontal pathogens, and the use of Mg-Cu in periodontal bone grafts has a great potential to prevent infections after periodontal surgery.
American Psychological Association (APA)
Zhao, Xue& Wan, Peng& Wang, Hongyan& Zhang, Shuwei& Liu, Jingbo& Chang, Chunrong…[et al.]. 2020. An Antibacterial Strategy of Mg-Cu Bone Grafting in Infection-Mediated Periodontics. BioMed Research International،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1136730
Modern Language Association (MLA)
Zhao, Xue…[et al.]. An Antibacterial Strategy of Mg-Cu Bone Grafting in Infection-Mediated Periodontics. BioMed Research International No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1136730
American Medical Association (AMA)
Zhao, Xue& Wan, Peng& Wang, Hongyan& Zhang, Shuwei& Liu, Jingbo& Chang, Chunrong…[et al.]. An Antibacterial Strategy of Mg-Cu Bone Grafting in Infection-Mediated Periodontics. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1136730
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1136730