Contrast Microsphere Destruction by a Continuous Flow Ventricular Assist Device: An In Vitro Evaluation Using a Mock Circulation Loop
Joint Authors
Fraser, John F.
Platts, David G.
Bartnikowski, Nicole
Scalia, Gregory M.
Gregory, Shaun D.
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-08-13
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Objectives.
Transthoracic echocardiography (TTE) is fundamental in managing patients supported with ventricular assist devices (VAD).
However imaging can be difficult in these patients.
Contrast improves image quality but they are hydrodynamically fragile agents.
The aim was to assess contrast concentration following passage through a VAD utilising a mock circulation loop (MCL).
Methods.
Heartware continuous flow (CF) VAD was incorporated into a MCL.
Definity® contrast was infused into the MCL with imaging before and after CF-VAD.
5 mm2 regions of interest were used to obtain signal intensity (decibels), as a surrogate of contrast concentration.
Results.
Four pump speeds revealed significant reduction in contrast signal intensity after CF-VAD compared to before CF-VAD (all p<0.0001).
Combined pre- and postpump data at all speeds showed a 22.2% absolute reduction in contrast signal intensity across the CF-VAD (14.8 ± 0.8 dB prepump versus 11.6 ± 1.4 dB postpump; p<0.0001).
Mean signal intensity reduction at each speed showed an inverse relationship between speed and relative reduction in signal intensity.
Conclusion.
Contrast microsphere transit through a CF-VAD within a MCL resulted in significant reduction in signal intensity, consistent with destruction within the pump.
This was evident at all CF-VAD pump speeds but relative signal drop was inversely proportional to pump speed.
American Psychological Association (APA)
Platts, David G.& Bartnikowski, Nicole& Gregory, Shaun D.& Scalia, Gregory M.& Fraser, John F.. 2017. Contrast Microsphere Destruction by a Continuous Flow Ventricular Assist Device: An In Vitro Evaluation Using a Mock Circulation Loop. BioMed Research International،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1137333
Modern Language Association (MLA)
Platts, David G.…[et al.]. Contrast Microsphere Destruction by a Continuous Flow Ventricular Assist Device: An In Vitro Evaluation Using a Mock Circulation Loop. BioMed Research International No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1137333
American Medical Association (AMA)
Platts, David G.& Bartnikowski, Nicole& Gregory, Shaun D.& Scalia, Gregory M.& Fraser, John F.. Contrast Microsphere Destruction by a Continuous Flow Ventricular Assist Device: An In Vitro Evaluation Using a Mock Circulation Loop. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1137333
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1137333