Chimeric Antigen Receptor T Cell Exhaustion during Treatment for Hematological Malignancies
Joint Authors
Zhang, Zhen
Shen, Chunyi
Zhang, Yi
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-10-23
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Immunotherapy, especially based on chimeric antigen receptor (CAR) T cells, has achieved prominent success in the treatment of hematological malignancies.
However, approximately 30-50% of patients will have disease relapse following remission after receiving CD19-targeting CAR-T cells, with failure of maintaining a long-term effect.
Mechanisms underlying CAR-T therapy inefficiency consist of loss or modulation of target antigen and CAR-T cell poor persistence which mostly results from T cell exhaustion.
The unique features and restoration strategies of exhausted T cells (Tex) have been well described in solid tumors.
However, the overview associated with CAR-T cell exhaustion is relatively rare in hematological malignancies.
In this review, we summarize the characteristics, cellular, and molecular mechanisms of Tex cells as well as approaches to reverse CAR-T cell exhaustion in hematological malignancies, providing novel strategies for immunotherapies.
American Psychological Association (APA)
Shen, Chunyi& Zhang, Zhen& Zhang, Yi. 2020. Chimeric Antigen Receptor T Cell Exhaustion during Treatment for Hematological Malignancies. BioMed Research International،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1137644
Modern Language Association (MLA)
Shen, Chunyi…[et al.]. Chimeric Antigen Receptor T Cell Exhaustion during Treatment for Hematological Malignancies. BioMed Research International No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1137644
American Medical Association (AMA)
Shen, Chunyi& Zhang, Zhen& Zhang, Yi. Chimeric Antigen Receptor T Cell Exhaustion during Treatment for Hematological Malignancies. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1137644
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1137644