Antioxidant Activity of Telmisartan–Cu(II)‎ Nanoparticles Connected 2-Pyrimidinamine and Their Evaluation of Cytotoxicity Activities

Abstract EN

Copper nanoparticles (Cu-Nps) are one of the promising materials for the advancement of nanoscience and technology.

In this work, we synthesized telmisartan copper nanoparticles and 2-pyrimidinamines via Biginelli reaction using telmisartan copper nanoparticles (Cu-Nps) as a reusable catalyst.

The synthesis of 2-pyrimidinamine derivatives (1a-c) was achieved in water and under solvent-free condition (Green chemistry approach).

Synthesis of 2-pyrimidinamine with telmisartan copper nanoparticle (Cu-Nps–Pyr) unexpected product was also isolated from synthesis of 2-pyrimidinamine preparation.

Antioxidant and cytotoxic activities were carried out both in 2-pyrimidinamine (1a-1c) and 2-pyrimidinamine with telmisartan copper nanoparticles (Cu-Nps–Pyr).

The synthesized 2-pyrimidinamine derivatives (1a-c) were characterized from FT-IR, 1H and 13C NMR spectroscopy, mass and elemental analyses.

The synthesized telmisartan copper nanoparticles (Cu-Nps) were characterized from UV spectroscopy, XRD, SEM, EDX, AFM (atomic force microscopy), profile, waviness, and roughness analyses.

Antioxidant activity was screened based on ABTS⋅+ radical scavenging and linoleic acid peroxidation performance.

Cu-Nps–Pyr-1b showed substantial antioxidant (97.2%) activity against ABTS⋅+ assay and 91.2% activity against AAPH assays compared with Trolox.

Cytotoxicity was evaluated using HepG2, HeLa, and MCF-7 cell lines, the Cu-Nps–Pyr-1a is high in toxicities (GI50=0.01 μm) against the HeLa cancel cell line compared with doxorubicin.

The developed copper NPs with 2-pyrimidinamine (Cu-Nps–Pyr) could provide promising advances as antioxidant activities; this nanocomposition could be considered an anticancer treatment in future investigations.