Association of the Differences in Average Glandular Dose with Breast Cancer Risk
Joint Authors
He, Zilong
Lin, Xiaojia
Ma, Le
Cai, Yuxing
Chen, Weiguo
Qin, Genggeng
Zeng, Hui
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-11-19
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Objectives.
To compare the differences in normalized average glandular dose (NAGD) between the breasts of healthy subjects and those of cancer patients and to determine if the NAGD difference is associated with breast cancer risk and improves breast cancer classification.
Materials and Methods.
Craniocaudal view and mediolateral view full-field digital mammography (FFDM) images were obtained from 1682 healthy subjects whose breasts were categorized as Breast Imaging-Reporting and Data System (BI-RADS) I or II and from 811 biopsy-confirmed unilateral breast cancer patients whose breasts on the contralateral side were category I or II.
Both populations were randomized into training and test sets.
Multivariate logistic regression analysis was used to build the breast cancer risk assessment model, and the area under the receiver operating characteristic curve (Az) was used to evaluate the model.
Twenty-two breast cancer patients who were originally categorized as BI-RADS I or II for both breasts, but were diagnosed with unilateral biopsy-confirmed breast cancer subsequently, were included to validate the model.
Results.
The NAGD differences in both FFDM images between tumor-bearing breasts and the healthy breasts of patients were significantly higher than those in healthy subjects (P<0.001).
The model with NAGD differences had a higher Az value than the model without NAGD differences.
While there was no NAGD differences between originally healthy breasts of breast cancer patients, significant NAGD differences between now tumor-bearing breasts and the then previously healthy breasts were found in both FFDM images.
Conclusions.
NAGD differences between both breasts can be included in the breast cancer risk assessment model to evaluate breast cancer risk.
American Psychological Association (APA)
Ma, Le& Cai, Yuxing& Lin, Xiaojia& He, Zilong& Zeng, Hui& Chen, Weiguo…[et al.]. 2020. Association of the Differences in Average Glandular Dose with Breast Cancer Risk. BioMed Research International،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1137879
Modern Language Association (MLA)
Ma, Le…[et al.]. Association of the Differences in Average Glandular Dose with Breast Cancer Risk. BioMed Research International No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1137879
American Medical Association (AMA)
Ma, Le& Cai, Yuxing& Lin, Xiaojia& He, Zilong& Zeng, Hui& Chen, Weiguo…[et al.]. Association of the Differences in Average Glandular Dose with Breast Cancer Risk. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1137879
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1137879