Coenzyme Q10 Sunscreen Prevents Progression of Ultraviolet-Induced Skin Damage in Mice
Joint Authors
Zhong, Zhangfeng
Wu, Haiyou
Lin, Sien
Qiu, Chuqun
Xie, Peitao
Lv, Simin
Cui, Liao
Wu, Tie
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-08-19
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The level of sun ultraviolet ray reaching the surface of the earth is increasing severely due to the rapid development of the society and environmental destruction.
Excessive exposure to ultraviolet radiation causes skin damage and photoaging.
Therefore, it is emerged to develop effective sunscreen to prevent ultraviolet-induced skin damage.
This study was aimed at investigating the effects of Coenzyme Q10 (CoQ10) sunscreen on the prevention of ultraviolet B radiation- (UVB-) induced mouse skin damage.
Three-month-old female mice were used, and they were randomly divided into four groups: control, model, CoQ10, and titanium dioxide (TiO2; positive control) groups.
Our results showed that body weight, superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activities, and DNA (cytosine-5)-methyltransferase 1 (DNMT1) protein expression were significantly decreased, while malondialdehyde (MDA) activity and metalloproteinase-1 (MMP-1) level were increased in UVB-treated mice.
Besides, the stratum corneum was shed from the skin surface in the model group compared with the control group.
In contrast, CoQ10 sunscreen prevented from UVB-induced skin damage, as well as reversing SOD, GSH-Px, and MDA activities, and MMP-1 and DNMT1 levels.
Taken together, the current study provided further evidence on the prevention of UVB-induced skin damage by CoQ10 and its underlying mechanisms.
American Psychological Association (APA)
Wu, Haiyou& Zhong, Zhangfeng& Lin, Sien& Qiu, Chuqun& Xie, Peitao& Lv, Simin…[et al.]. 2020. Coenzyme Q10 Sunscreen Prevents Progression of Ultraviolet-Induced Skin Damage in Mice. BioMed Research International،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1137926
Modern Language Association (MLA)
Wu, Haiyou…[et al.]. Coenzyme Q10 Sunscreen Prevents Progression of Ultraviolet-Induced Skin Damage in Mice. BioMed Research International No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1137926
American Medical Association (AMA)
Wu, Haiyou& Zhong, Zhangfeng& Lin, Sien& Qiu, Chuqun& Xie, Peitao& Lv, Simin…[et al.]. Coenzyme Q10 Sunscreen Prevents Progression of Ultraviolet-Induced Skin Damage in Mice. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1137926
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1137926