Preventive Effect of Cashew-Derived Protein Hydrolysate with High Fiber on Cerebral Ischemia
Joint Authors
Wattanathorn, Jintanaporn
Tiamkao, Somsak
Tong-Un, Terdthai
Wannanon, Panakaporn
Muchimapura, Supaporn
Thukham-mee, Wipawee
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-12-31
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
This study aimed to determine the protective effect of cashew nut-derived protein hydrolysate with high dietary fiber (AO) in cerebral ischemic rats induced by the occlusion of right middle cerebral artery (Rt.MCAO).
Acute toxicity was determined and data showed that LD50 of AO > 5000 mg/kg BW.
To determine the cerebroprotective effect of AO, male Wistar rats were orally given AO at doses of 2, 10, and 50 mg/kg for 14 days and subjected to Rt.MCAO.
Brain infarction volume, neurological score, spatial memory, serum lipid profiles, and C-reactive protein together with the brain oxidative stress status were assessed.
All doses of AO significantly decreased brain infarction in cortex, hippocampus, and striatum together with the decreased oxidative stress status.
The improvement of spatial memory and serum C-reactive protein were also observed in MCAO rats which received AO at all doses.
In addition, the decreased serum cholesterol, TG, and LDL but increased HDL were observed in MCAO rats which received high dose of AO.
Taken all together, AO is the potential protectant against cerebral ischemia.
The improvement of oxidative stress, inflammation, and dyslipidemia might play roles in the actions.
However, further researches are required to understand the precise underlying mechanism.
American Psychological Association (APA)
Wattanathorn, Jintanaporn& Thukham-mee, Wipawee& Muchimapura, Supaporn& Wannanon, Panakaporn& Tong-Un, Terdthai& Tiamkao, Somsak. 2017. Preventive Effect of Cashew-Derived Protein Hydrolysate with High Fiber on Cerebral Ischemia. BioMed Research International،Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1137964
Modern Language Association (MLA)
Wattanathorn, Jintanaporn…[et al.]. Preventive Effect of Cashew-Derived Protein Hydrolysate with High Fiber on Cerebral Ischemia. BioMed Research International No. 2017 (2017), pp.1-14.
https://search.emarefa.net/detail/BIM-1137964
American Medical Association (AMA)
Wattanathorn, Jintanaporn& Thukham-mee, Wipawee& Muchimapura, Supaporn& Wannanon, Panakaporn& Tong-Un, Terdthai& Tiamkao, Somsak. Preventive Effect of Cashew-Derived Protein Hydrolysate with High Fiber on Cerebral Ischemia. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1137964
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1137964