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Systematic Identification and Molecular Characteristics of Long Noncoding RNAs in Pig Tissues
Joint Authors
Li, Kui
Yang, Yalan
Zhou, Rong
Zhu, Shiyun
Li, Xunbi
Li, Hua
Yu, Hui
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-09-14
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Long noncoding RNAs (lncRNAs) are non-protein-coding RNAs that are involved in a variety of biological processes.
The pig is an important farm animal and an ideal biomedical model.
In this study, we performed a genome-wide scan for lncRNAs in multiple tissue types from pigs.
A total of 118 million paired-end 90 nt clean reads were obtained via strand-specific RNA sequencing, 80.4% of which were aligned to the pig reference genome.
We developed a stringent bioinformatics pipeline to identify 2,139 high-quality multiexonic lncRNAs.
The characteristic analysis revealed that the novel lncRNAs showed relatively shorter transcript length, fewer exons, and lower expression levels in comparison with protein-coding genes (PCGs).
The guanine-cytosine (GC) content of the protein-coding exons and introns was significantly higher than that of the lncRNAs.
Moreover, the single nucleotide polymorphism (SNP) density of lncRNAs was significantly higher than that of PCGs.
Conservation analysis revealed that most lncRNAs were evolutionarily conserved among pigs, humans, and mice, such as CUFF.253988.1, which shares homology with human long noncoding RNA MALAT1.
The findings of our study significantly increase the number of known lncRNAs in pigs.
American Psychological Association (APA)
Yang, Yalan& Zhou, Rong& Zhu, Shiyun& Li, Xunbi& Li, Hua& Yu, Hui…[et al.]. 2017. Systematic Identification and Molecular Characteristics of Long Noncoding RNAs in Pig Tissues. BioMed Research International،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1137976
Modern Language Association (MLA)
Yang, Yalan…[et al.]. Systematic Identification and Molecular Characteristics of Long Noncoding RNAs in Pig Tissues. BioMed Research International No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1137976
American Medical Association (AMA)
Yang, Yalan& Zhou, Rong& Zhu, Shiyun& Li, Xunbi& Li, Hua& Yu, Hui…[et al.]. Systematic Identification and Molecular Characteristics of Long Noncoding RNAs in Pig Tissues. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1137976
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1137976