The Role of Interleukin-17, Interleukin-23, and Transforming Growth Factor-β in Pregnancy Complicated by Placental Insufficiency
Joint Authors
Bojarska-Junak, Agnieszka
Darmochwal-Kolarz, Dorota
Kolarz, Bogdan
Oleszczuk, Jan
Michalak, Magdalena
Przegalinska-Kalamucka, Monika
Sliwa, Dariusz
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-06-15
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Aim.
The aim of the study was to evaluate the role of Interleukin-17 (IL-17), Interleukin-23 (IL-23), and transforming growth factor-β (TGF-β) in pregnancy complicated by placental insufficiency and in normal pregnancy.
Material and Methods.
The study comprised 34 patients with pregnancy complicated by fetal growth restriction (FGR) associated with preeclampsia (PE), as well as 35 healthy pregnant women.
The concentrations of IL-17, IL-23, and TGF-β in sera from maternal peripheral blood were determined by an immunoenzymatic assay.
Results.
There were higher concentrations of IL-17 in the study group when compared to the controls.
In the group of patients with placental insufficiency, the levels of IL-17 positively correlated with systolic blood pressure (R=0.42, p<0.01).
The study obtained comparable concentrations of IL-23 in both studied groups.
The concentrations of TGF-β were significantly lower in pregnancy complicated by the insufficiency of placenta when compared to the controls.
Conclusions.
It seems possible that the increased concentrations of IL-17 and the deficiency of TGF-β in pregnancy complicated by FGR and PE can be responsible for the activation of inflammatory response observed in PE cases.
American Psychological Association (APA)
Darmochwal-Kolarz, Dorota& Michalak, Magdalena& Kolarz, Bogdan& Przegalinska-Kalamucka, Monika& Bojarska-Junak, Agnieszka& Sliwa, Dariusz…[et al.]. 2017. The Role of Interleukin-17, Interleukin-23, and Transforming Growth Factor-β in Pregnancy Complicated by Placental Insufficiency. BioMed Research International،Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1138276
Modern Language Association (MLA)
Darmochwal-Kolarz, Dorota…[et al.]. The Role of Interleukin-17, Interleukin-23, and Transforming Growth Factor-β in Pregnancy Complicated by Placental Insufficiency. BioMed Research International No. 2017 (2017), pp.1-5.
https://search.emarefa.net/detail/BIM-1138276
American Medical Association (AMA)
Darmochwal-Kolarz, Dorota& Michalak, Magdalena& Kolarz, Bogdan& Przegalinska-Kalamucka, Monika& Bojarska-Junak, Agnieszka& Sliwa, Dariusz…[et al.]. The Role of Interleukin-17, Interleukin-23, and Transforming Growth Factor-β in Pregnancy Complicated by Placental Insufficiency. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1138276
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1138276