Polyketide-Terpene Hybrid Metabolites from an Endolichenic Fungus Pestalotiopsis sp.
Joint Authors
Zou, Zhongmei
Yuan, Chao
Ding, Gang
Wang, Hai-Ying
Guo, Yu-Hua
Shang, Hai
Ma, Xiao-Jun
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-05-16
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Five new polyketide-terpene hybrid metabolites (1–5) with highly functionalized groups, together with six known derivatives (6–11), were isolated from the endolichenic fungus Pestalotiopsis sp.
Their structures were elucidated by extensive NMR experiments including 1H, 13C, HMQC, COSY, and HMBC.
The relative configurations of the new compounds were determined by analysis of coupling constants and ROESY correlations.
The absolute configurations especially the secondary alcohol at C-15 in 1 and secondary alcohol at C-14 in 5 were established via the CD experiments of the in situ formed [Rh2(OCOCF3)4] complex with the acetonide derivatives.
These compounds were tested for their inhibition activity against six plant pathogens.
Compounds 1 and 5 exhibited pronounced efficiency against Fusarium oxysporum, and compounds 5 and 6 potently inhibited Fusarium gramineum with MIC value of 8 µg/mL, which revealed the plausible ecological role of endolichenic fungus in providing chemical protection for its host lichen in the fungus-plant relationship.
The biosynthetic pathway of compounds 1–11 was postulated for the first time, which paved the way for its further biosynthesis research.
American Psychological Association (APA)
Yuan, Chao& Ding, Gang& Wang, Hai-Ying& Guo, Yu-Hua& Shang, Hai& Ma, Xiao-Jun…[et al.]. 2017. Polyketide-Terpene Hybrid Metabolites from an Endolichenic Fungus Pestalotiopsis sp.. BioMed Research International،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1138314
Modern Language Association (MLA)
Yuan, Chao…[et al.]. Polyketide-Terpene Hybrid Metabolites from an Endolichenic Fungus Pestalotiopsis sp.. BioMed Research International No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1138314
American Medical Association (AMA)
Yuan, Chao& Ding, Gang& Wang, Hai-Ying& Guo, Yu-Hua& Shang, Hai& Ma, Xiao-Jun…[et al.]. Polyketide-Terpene Hybrid Metabolites from an Endolichenic Fungus Pestalotiopsis sp.. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1138314
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1138314