Hyperuricemia is a Risk Factor for One-Year Overall Survival in Elderly Female Patients with Acute Coronary Syndrome
Joint Authors
Tang, Liang
Fang, Zhen-fei
Hu, Xin-qun
Tai, Shi
Li, Xuping
Zhu, Zhaowei
Yang, Hui
Fu, Liyao
Zhou, Shenghua
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-02-22
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Background.
Hyperuricemia is a risk factor for cardiovascular diseases, but the impact of hyperuricemia and sex-related disparities is not fully clear in elderly patients with acute coronary syndrome (ACS).
Objective.
To investigate the association between hyperuricemia and 1-year all-cause mortality in elderly patients with ACS.
Methods.
This retrospective cohort study included 711 consecutive ACS patients aged ≥75 years, hospitalized in our center between January 2013 and December 2017.
Serum uric acid (sUA), in-hospital events, and 1-year follow-up were analyzed.
Multivariable logistic regression models were used to explore the risk factors for in-hospital events and 1-year all-cause mortality.
Results.
sUA levels were higher in males than in females (381.4 ± 110.1 vs.
349.3 ± 119.1 μmol/l, P<0.001).
Prevalence of hypertension (80.5% vs.
72.6%, P=0.020), atrial fibrillation (16.2% vs.
9.5%, P=0.008), and severe heart failure (61.0% vs.
44.2%, P<0.001) were higher in patients with hyperuricemia than in patients with normal sUA.
During the 1-year follow-up, 135 patients died (19.0%); all-cause mortality was higher in patients with hyperuricemia than in patients with normal sUA (23.1% vs.
16.7%, P=0.039).
Hyperuricemia is related to in-hospital ventricular tachycardia and 1-year all-cause mortality (OR = 1.799, 95% CI 1.050–3.081, P=0.033; OR = 1.512, 95% CI 1.028–2.225, P=0.036, respectively).
Multivariable regression analysis models showed that hyperuricemia was an independent risk factor of 1-year all-cause mortality in women (OR = 2.539, 95% CI 1.001–6.453, P=0.050), but not in men (OR = 0.931, 95% CI 0.466–1.858, P=0.839) after adjustment for confounding variables.
Conclusions.
Hyperuricemia is an independent risk factor for 1-year all-cause mortality in elderly female patients with ACS.
American Psychological Association (APA)
Tai, Shi& Li, Xuping& Zhu, Zhaowei& Tang, Liang& Yang, Hui& Fu, Liyao…[et al.]. 2020. Hyperuricemia is a Risk Factor for One-Year Overall Survival in Elderly Female Patients with Acute Coronary Syndrome. Cardiovascular Therapeutics،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1138586
Modern Language Association (MLA)
Tai, Shi…[et al.]. Hyperuricemia is a Risk Factor for One-Year Overall Survival in Elderly Female Patients with Acute Coronary Syndrome. Cardiovascular Therapeutics No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1138586
American Medical Association (AMA)
Tai, Shi& Li, Xuping& Zhu, Zhaowei& Tang, Liang& Yang, Hui& Fu, Liyao…[et al.]. Hyperuricemia is a Risk Factor for One-Year Overall Survival in Elderly Female Patients with Acute Coronary Syndrome. Cardiovascular Therapeutics. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1138586
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1138586