Serum Metabolomics Profiling to Identify Biomarkers for Unstable Angina
Joint Authors
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-05-24
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Although statistical evidence is clear regarding the dangerousness of unstable angina (UA), a form of coronary heart disease (CHD) characterised by high mortality and morbidity globally, it is important to recognise that diagnostic precision for the condition is unfavourable.
In the present research, to gain insight into candidate biomarkers, the author draws on 1H NMR-based serum metabolic profiling to analyze the unstable angina pectoris (UAP) metabolic signatures; this constitutes an effective way to produce medical diagnosis.
101 unstable angina pectoris patients and 132 healthy controls were enrolled and 22 serum samples from each group were analyzed.
Effective separation was noted regarding the UAP and control groups, and, for the former group considered in relation to their counterpart, the serum concentrations of Lac, m-I, lipid, VLDL, 3-HB, and LDL were higher whereas the concentrations of Thr, Cr, Cho, PC/GPC, Glu, Gln, Lys, HDL, Ile, Leu, and Val were lower.
The conclusion drawn in view of the results is that the plasma metabolomics examined by 1H NMR displayed promise for biomarker identification for UA.
In addition to this, the analysis illuminated the metabolic processes of UA.
American Psychological Association (APA)
Yao, Wei& Gao, Yuxia& Wan, Zheng. 2017. Serum Metabolomics Profiling to Identify Biomarkers for Unstable Angina. BioMed Research International،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1138695
Modern Language Association (MLA)
Yao, Wei…[et al.]. Serum Metabolomics Profiling to Identify Biomarkers for Unstable Angina. BioMed Research International No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1138695
American Medical Association (AMA)
Yao, Wei& Gao, Yuxia& Wan, Zheng. Serum Metabolomics Profiling to Identify Biomarkers for Unstable Angina. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1138695
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1138695