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Neutrophil-to-Lymphocyte Ratio Is a Potential Prognostic Biomarker in Patients with Ovarian Cancer: A Meta-Analysis
Joint Authors
Chen, Shubo
Zhang, Liu
Yan, Guangyue
Cheng, Sijin
Fathy, Abdel Hamid
Yan, Nana
Zhao, Yongzhao
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-07-26
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background and Aims.
Plenty of studies were conducted to explore the prognostic significance of neutrophil-to-lymphocyte ratio (NLR) in ovarian cancer with contradictory results.
This study aims to summarize the prognostic significance of NLR in patients with ovarian cancer.
Methods.
A literature search in PubMed, Cochrane Library, and Embase was conducted.
The endpoints were progression-free survival (PFS) and overall survival (OS).
Results.
Eleven studies involving a total of 2,892 patients were identified.
The results indicated that patients with high NLR had shorter PFS compared to patients with low NLR in ovarian cancer (HR = 1.55, 95% CI = 1.15–2.08, p=0.004, and I2=61%).
Similarly, high NLR was related to shorter OS (HR = 1.51, 95% CI = 1.03–2.23, p=0.04, and I2=85%).
Moreover, high NLR was significantly associated with shorter PFS when the NLR cut-off was less than 3.3 (p=0.03) or when treatment is operation (p=0.002).
In addition, high NLR was distinctly related to worse OS in Asian people (p = 0.04) or operation (p = 0.04).
Conclusion.
High NLR was associated with shorter PFS and shorter OS in ovarian cancer.
NLR is potentially a promising prognostic biomarker in patients with ovarian cancer.
American Psychological Association (APA)
Chen, Shubo& Zhang, Liu& Yan, Guangyue& Cheng, Sijin& Fathy, Abdel Hamid& Yan, Nana…[et al.]. 2017. Neutrophil-to-Lymphocyte Ratio Is a Potential Prognostic Biomarker in Patients with Ovarian Cancer: A Meta-Analysis. BioMed Research International،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1138810
Modern Language Association (MLA)
Chen, Shubo…[et al.]. Neutrophil-to-Lymphocyte Ratio Is a Potential Prognostic Biomarker in Patients with Ovarian Cancer: A Meta-Analysis. BioMed Research International No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1138810
American Medical Association (AMA)
Chen, Shubo& Zhang, Liu& Yan, Guangyue& Cheng, Sijin& Fathy, Abdel Hamid& Yan, Nana…[et al.]. Neutrophil-to-Lymphocyte Ratio Is a Potential Prognostic Biomarker in Patients with Ovarian Cancer: A Meta-Analysis. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1138810
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1138810