![](/images/graphics-bg.png)
Association between Fluorescent Advanced Glycation End-Products and Vascular Complications in Type 2 Diabetic Patients
Joint Authors
Bourdon, Emmanuel
Dubourg, Alexis Guerin
Rondeau, Philippe
Cournot, Maxime
Planesse, Cynthia
Debussche, Xavier
Meilhac, Olivier
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-12-06
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Objectives.
Diabetes is a major health problem associated with hyperglycemia and chronically increased oxidative stress and enhanced formation of advanced glycation end-products (AGEs).
The aim of this study was to determine whether oxidative plasma biomarkers in diabetic patients could be evidenced and associated with vascular complications.
Methods.
Oxidative stress biomarkers such as thiols, ischemia-modified albumin (IMA), glycated albumin (GA), fructosamine, and AGEs were measured in 75 patients with poorly controlled type 2 diabetes (HbA1c > 7.5%) with (44) or without (31) vascular disease and in 31 nondiabetic controls.
Results.
Most biomarkers of oxidation and glycation were significantly increased in diabetic patients in comparison with nondiabetics.
Fructosamines, GA, IMA, and AGEs were positively correlated and levels of fluorescent AGEs were significantly increased in the plasma from patients presenting vascular complication.
Conclusions.
These results bring new evidence for the potential interest of glycated albumin, oxidative stress, and glycoxidation parameters in the monitoring of type 2 diabetic patients.
Furthermore, it emphasizes fluorescent AGEs as a putative indicator for vascular event prediction in diabetic patients.
American Psychological Association (APA)
Dubourg, Alexis Guerin& Cournot, Maxime& Planesse, Cynthia& Debussche, Xavier& Meilhac, Olivier& Rondeau, Philippe…[et al.]. 2017. Association between Fluorescent Advanced Glycation End-Products and Vascular Complications in Type 2 Diabetic Patients. BioMed Research International،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1138844
Modern Language Association (MLA)
Dubourg, Alexis Guerin…[et al.]. Association between Fluorescent Advanced Glycation End-Products and Vascular Complications in Type 2 Diabetic Patients. BioMed Research International No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1138844
American Medical Association (AMA)
Dubourg, Alexis Guerin& Cournot, Maxime& Planesse, Cynthia& Debussche, Xavier& Meilhac, Olivier& Rondeau, Philippe…[et al.]. Association between Fluorescent Advanced Glycation End-Products and Vascular Complications in Type 2 Diabetic Patients. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1138844
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1138844