![](/images/graphics-bg.png)
Hepatitis C Virus Screening of High-Risk Patients in a Canadian Emergency Department
Joint Authors
Swain, Mark G.
Ragan, Kelsey
Pandya, Anjali
Holotnak, Tristan
Koger, Katrina
Collins, Neil
Source
Canadian Journal of Gastroenterology and Hepatology
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-02-18
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
Approximately 0.7% of the Canadian population is infected with hepatitis C virus (HCV), and many individuals are unaware of their infection.
Our objectives were to utilize an emergency department (ED) based point-of-care (POC) HCV screening test to describe our local population and estimate the proportion of high-risk patients in our population with undiagnosed HCV.
Methods.
A convenience sample of medically stable patients (≥18 years) presenting to a community ED in Calgary, AB, between April and July 2018 underwent rapid clinical screening for HCV risk factors, including history of injection drug use, healthcare in endemic countries, and other recognized criteria.
High-risk patients were offered POC HCV testing.
Antibody-positive patients underwent HCV-RNA testing and were linked to hepatology care.
The primary outcome was the proportion of new HCV diagnoses in the high-risk population.
Results.
Of the 999 patients screened by survey, 247 patients (24.7%) were high-risk and eligible for testing.
Of these, 123 (49.8%) were from HCV-endemic countries, while 63 (25.5%) and 31 (12.6%) patients endorsed a history of incarceration and intravenous drug use (IVDU), respectively.
A total of 144 (58.3%) eligible patients agreed to testing.
Of these, 6 patients were POC-positive (4.2%, CI 0.9–7.4%); all 6 had antibodies detected on confirmatory lab testing and 4 had detectable HCV-RNA viral loads in follow-up.
Notably, 103 (41.7%) patients declined POC testing.
Interpretation.
Among 144 high-risk patients who agreed to testing, the rate of undiagnosed HCV infection was 4.2%, and the rate of undiagnosed HCV infection with detectable viral load was 2.8%.
Many patients with high-risk clinical criteria refused POC testing.
It is unknown if tested and untested groups have the same disease prevalence.
This study shows that ED HCV screening is feasible and that a small number of previously undiagnosed patients can be identified and linked to potentially life-changing care.
American Psychological Association (APA)
Ragan, Kelsey& Pandya, Anjali& Holotnak, Tristan& Koger, Katrina& Collins, Neil& Swain, Mark G.. 2020. Hepatitis C Virus Screening of High-Risk Patients in a Canadian Emergency Department. Canadian Journal of Gastroenterology and Hepatology،Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1139019
Modern Language Association (MLA)
Ragan, Kelsey…[et al.]. Hepatitis C Virus Screening of High-Risk Patients in a Canadian Emergency Department. Canadian Journal of Gastroenterology and Hepatology No. 2020 (2020), pp.1-6.
https://search.emarefa.net/detail/BIM-1139019
American Medical Association (AMA)
Ragan, Kelsey& Pandya, Anjali& Holotnak, Tristan& Koger, Katrina& Collins, Neil& Swain, Mark G.. Hepatitis C Virus Screening of High-Risk Patients in a Canadian Emergency Department. Canadian Journal of Gastroenterology and Hepatology. 2020. Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1139019
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1139019