Complete Response of Synchronous Liver Metastasis in a Pancreatic Ductal Adenocarcinoma, When Surgery Could Represent a Therapeutic Option
Joint Authors
Argentiero, Antonella
Calabrese, Angela
Sciacovelli, Angela Monica
Delcuratolo, Sabina
Solimando, Antonio Giovanni
Brunetti, Oronzo
Source
Canadian Journal of Gastroenterology and Hepatology
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-10-10
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Metastatic pancreatic ductal adenocarcinoma (PDAC) is characterized by poor prognosis and short survival.
Today, the use of new polytherapeutic regimens increases clinical outcome of these patients opening new clinical scenario.
A crucial issue related to the actual improvement achieved with these new regimens is represented by the occasional possibility to observe a radiological complete response of metastatic lesions in patients with synchronous primary tumor.
What could be the best therapeutic management of these patients? Could surgery represent an indication? Herein, we reported a case of a patient with PDAC of the head with multiple liver metastases, who underwent first-line chemotherapy with mFOLFIRINOX.
After 10 cycles, he achieved a complete radiological response of liver metastases and a partial response of pancreatic lesion.
A duodenocephalopancreasectomy was performed.
Due to liver a lung metastases after 8 months from surgery, a second-line therapy was started with a disease-free survival and overall survival of 8 months and 45 months, respectively.
Improvement in the molecular characterization of PDAC could help in the selection of patients suitable for multimodal treatments.
This trial is registered with NCT02892305 and NCT00855634.
American Psychological Association (APA)
Argentiero, Antonella& Calabrese, Angela& Sciacovelli, Angela Monica& Delcuratolo, Sabina& Solimando, Antonio Giovanni& Brunetti, Oronzo. 2020. Complete Response of Synchronous Liver Metastasis in a Pancreatic Ductal Adenocarcinoma, When Surgery Could Represent a Therapeutic Option. Canadian Journal of Gastroenterology and Hepatology،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1139038
Modern Language Association (MLA)
Argentiero, Antonella…[et al.]. Complete Response of Synchronous Liver Metastasis in a Pancreatic Ductal Adenocarcinoma, When Surgery Could Represent a Therapeutic Option. Canadian Journal of Gastroenterology and Hepatology No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1139038
American Medical Association (AMA)
Argentiero, Antonella& Calabrese, Angela& Sciacovelli, Angela Monica& Delcuratolo, Sabina& Solimando, Antonio Giovanni& Brunetti, Oronzo. Complete Response of Synchronous Liver Metastasis in a Pancreatic Ductal Adenocarcinoma, When Surgery Could Represent a Therapeutic Option. Canadian Journal of Gastroenterology and Hepatology. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1139038
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1139038