Orthostatic Intolerance and Postural Orthostatic Tachycardia Syndrome in Joint Hypermobility SyndromeEhlers-Danlos Syndrome, Hypermobility Type: Neurovegetative Dysregulation or Autonomic Failure?
Joint Authors
Celletti, Claudia
Camerota, Filippo
Castori, Marco
Censi, Federica
Gioffrè, Laura
Calcagnini, Giovanni
Strano, Stefano
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-02-12
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
Joint hypermobility syndrome/Ehlers-Danlos syndrome, hypermobility type (JHS/EDS-HT), is a hereditary connective tissue disorder mainly characterized by generalized joint hypermobility, skin texture abnormalities, and visceral and vascular dysfunctions, also comprising symptoms of autonomic dysfunction.
This study aims to further evaluate cardiovascular autonomic involvement in JHS/EDS-HT by a battery of functional tests.
Methods.
The response to cardiovascular reflex tests comprising deep breathing, Valsalva maneuver, 30/15 ratio, handgrip test, and head-up tilt test was studied in 35 JHS/EDS-HT adults.
Heart rate and blood pressure variability was also investigated by spectral analysis in comparison to age and sex healthy matched group.
Results.
Valsalva ratio was normal in all patients, but 37.2% of them were not able to finish the test.
At tilt, 48.6% patients showed postural orthostatic tachycardia, 31.4% orthostatic intolerance, 20% normal results.
Only one patient had orthostatic hypotension.
Spectral analysis showed significant higher baroreflex sensitivity values at rest compared to controls.
Conclusions.
This study confirms the abnormal cardiovascular autonomic profile in adults with JHS/EDS-HT and found the higher baroreflex sensitivity as a potential disease marker and clue for future research.
American Psychological Association (APA)
Celletti, Claudia& Camerota, Filippo& Castori, Marco& Censi, Federica& Gioffrè, Laura& Calcagnini, Giovanni…[et al.]. 2017. Orthostatic Intolerance and Postural Orthostatic Tachycardia Syndrome in Joint Hypermobility SyndromeEhlers-Danlos Syndrome, Hypermobility Type: Neurovegetative Dysregulation or Autonomic Failure?. BioMed Research International،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1139374
Modern Language Association (MLA)
Celletti, Claudia…[et al.]. Orthostatic Intolerance and Postural Orthostatic Tachycardia Syndrome in Joint Hypermobility SyndromeEhlers-Danlos Syndrome, Hypermobility Type: Neurovegetative Dysregulation or Autonomic Failure?. BioMed Research International No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1139374
American Medical Association (AMA)
Celletti, Claudia& Camerota, Filippo& Castori, Marco& Censi, Federica& Gioffrè, Laura& Calcagnini, Giovanni…[et al.]. Orthostatic Intolerance and Postural Orthostatic Tachycardia Syndrome in Joint Hypermobility SyndromeEhlers-Danlos Syndrome, Hypermobility Type: Neurovegetative Dysregulation or Autonomic Failure?. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1139374
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1139374