Evaluation of Risk Factors for Vertebral Compression Fracture after Carbon-Ion Radiotherapy for Primary Spinal and Paraspinal Sarcoma
Joint Authors
Nakashima, Yasuharu
Matsumoto, Yoshihiro
Fukushi, Jun-ichi
Kawaguchi, Ken-ichi
Setsu, Nokitaka
IIda, Keiichiro
Endo, Makoto
Okada, Seiji
Bekki, Hirofumi
Shinoto, Makoto
Imai, Reiko
Kamada, Tadashi
Shioyama, Yoshiyuki
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-07-26
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background and Purpose.
Carbon-ion radiotherapy (C-ion RT) was effective therapy for inoperable spinal and paraspinal sarcomas.
However, a significant adverse event following radiotherapies is vertebral compression fractures (VCFs).
In this study, we investigated the incidence of and risk factors for post-C-ion RT VCFs in patients with spinal or paraspinal sarcomas.
Material and Methods.
Thirty consecutive patients with spinal or paraspinal sarcomas treated with C-ion RT were retrospectively reviewed.
Various clinical parameters and the Spinal Instability Neoplastic Score (SINS) were used to evaluate the risk factors for post-C-ion RT VCFs.
Results.
The overall incidence of VCFs was 23% (median time: 7 months).
Patients with VCFs showed a markedly higher SINS score (median value, 9 points) than those without VCF (5 points).
The area under the receiver operating characteristic curve for the SINS score was 0.88, and the optimum SINS cut-off score was 8 points.
The cumulative incidence of VCFs at 1 year was 9% for patients with a SINS score under 8 points, versus 80% for those with a SINS score of 8 points or higher (p<0.0001).
Conclusions.
In patients with a SINS score of 8 points or higher, referral to a spine surgeon for stabilization and multidisciplinary discussion is appropriate.
American Psychological Association (APA)
Matsumoto, Yoshihiro& Shinoto, Makoto& Endo, Makoto& Setsu, Nokitaka& IIda, Keiichiro& Fukushi, Jun-ichi…[et al.]. 2017. Evaluation of Risk Factors for Vertebral Compression Fracture after Carbon-Ion Radiotherapy for Primary Spinal and Paraspinal Sarcoma. BioMed Research International،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1139545
Modern Language Association (MLA)
Matsumoto, Yoshihiro…[et al.]. Evaluation of Risk Factors for Vertebral Compression Fracture after Carbon-Ion Radiotherapy for Primary Spinal and Paraspinal Sarcoma. BioMed Research International No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1139545
American Medical Association (AMA)
Matsumoto, Yoshihiro& Shinoto, Makoto& Endo, Makoto& Setsu, Nokitaka& IIda, Keiichiro& Fukushi, Jun-ichi…[et al.]. Evaluation of Risk Factors for Vertebral Compression Fracture after Carbon-Ion Radiotherapy for Primary Spinal and Paraspinal Sarcoma. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1139545
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1139545