Cognitive Impairment in Relapsing-Remitting Multiple Sclerosis Patients with Very Mild Clinical Disability
Joint Authors
Fabrizio, Vernieri
Curcio, Giuseppe
Migliore, S.
Ghazaryan, A.
Simonelli, I.
Squitieri, F.
Landi, D.
Palmieri, M. G.
Filippi, M. M.
Moffa, F.
Pasqualetti, Patrizio
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-08-15
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Cognitive dysfunction affects 40–65% of multiple sclerosis (MS) patients and can occur in the early stages of the disease.
This study aimed to explore cognitive functions by means of the Italian version of the minimal assessment of cognitive function in MS (MACFIMS) in relapsing-remitting MS (RRMS) patients with very mild clinical disability to identify the primarily involved cognitive functions.
Ninety-two consecutive RRMS patients with Expanded Disability Status Scale (EDSS) scores ≤ 2.5 and forty-two healthy controls (HC) were investigated.
Our results show that 51.1% of MS patients have cognitive dysfunction compared to HC.
An impairment of verbal and visual memory, working memory, and executive functions was found in the RRMS group.
After subgrouping RRMS by EDSS, group 1 (EDSS ≤ 1.5) showed involvement of verbal memory and executive functions; moreover, group 2 (2 ≤ EDSS ≤ 2.5) patients were also impaired in information processing speed and visual memory.
Our results show that utilizing a comprehensive neuropsychological assessment, approximately half of MS patients with very mild physical disability exhibit cognitive impairment with a primary involvement of prefrontal cognitive functions.
Detecting impairment of executive functions at an early clinical stage of disease could be useful to promptly enroll MS patients in targeted rehabilitation.
American Psychological Association (APA)
Migliore, S.& Ghazaryan, A.& Simonelli, I.& Pasqualetti, Patrizio& Squitieri, F.& Curcio, Giuseppe…[et al.]. 2017. Cognitive Impairment in Relapsing-Remitting Multiple Sclerosis Patients with Very Mild Clinical Disability. Behavioural Neurology،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1139788
Modern Language Association (MLA)
Migliore, S.…[et al.]. Cognitive Impairment in Relapsing-Remitting Multiple Sclerosis Patients with Very Mild Clinical Disability. Behavioural Neurology No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1139788
American Medical Association (AMA)
Migliore, S.& Ghazaryan, A.& Simonelli, I.& Pasqualetti, Patrizio& Squitieri, F.& Curcio, Giuseppe…[et al.]. Cognitive Impairment in Relapsing-Remitting Multiple Sclerosis Patients with Very Mild Clinical Disability. Behavioural Neurology. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1139788
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1139788