Detailed Histologic Evaluation of Eosinophilic Esophagitis in Pediatric Patients Presenting with Dysphagia or Abdominal Pain and Comparison of the Histology between the Two Groups
Joint Authors
Gunasekaran, Thirumazhisai
Schwartz, Alan
Chu, Christopher
Ronquillo, Nemencio
Adley, Brian
Borgen, Kristina
Newberry, Robert
Berman, James
Chennuri, Rohini
Source
Canadian Journal of Gastroenterology and Hepatology
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-12-17
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
EoE in children presents with four main symptoms.
Most common symptoms exhibited by our clinic population are dysphagia (D) and abdominal pain (AP).
Despite similar treatments, we found in an earlier study that the outcomes between these two groups were different.
Therefore, we investigated if there exist any histological differences between these groups that could further our knowledge of EoE.
Aim.
To compare esophageal histology in detail, apart from the eosinophil count, between EoE-D and EoE-AP.
Method.
Biopsies of patients with EoE-D and EoE-AP were reevaluated for 10 additional histological criteria, in addition to the eosinophil count.
Results.
Both groups had 67 patients; peak mean eosinophil was 33.9 and 31.55 for EoE-D and EoE-AP (p<0.05).
Eosinophilic microabscesses, superficial layering of eosinophils, and epithelial desquamation were twice as common and significant in EoE-D group than EoE-AP.
Eosinophil distribution around rete pegs was also significantly higher in EoE-D group.
The remaining criteria were numerically higher in EoE-D, but not significant, with the exception of rete peg elongation.
Conclusion.
EoE-D patients have significantly higher eosinophils compared to EoE-AP, and the level of inflammation as seen from eosinophil microabscesses, superficial layering, desquamation, and the distribution around rete pegs is significantly higher.
American Psychological Association (APA)
Gunasekaran, Thirumazhisai& Chu, Christopher& Ronquillo, Nemencio& Chennuri, Rohini& Adley, Brian& Borgen, Kristina…[et al.]. 2017. Detailed Histologic Evaluation of Eosinophilic Esophagitis in Pediatric Patients Presenting with Dysphagia or Abdominal Pain and Comparison of the Histology between the Two Groups. Canadian Journal of Gastroenterology and Hepatology،Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1141403
Modern Language Association (MLA)
Gunasekaran, Thirumazhisai…[et al.]. Detailed Histologic Evaluation of Eosinophilic Esophagitis in Pediatric Patients Presenting with Dysphagia or Abdominal Pain and Comparison of the Histology between the Two Groups. Canadian Journal of Gastroenterology and Hepatology No. 2017 (2017), pp.1-6.
https://search.emarefa.net/detail/BIM-1141403
American Medical Association (AMA)
Gunasekaran, Thirumazhisai& Chu, Christopher& Ronquillo, Nemencio& Chennuri, Rohini& Adley, Brian& Borgen, Kristina…[et al.]. Detailed Histologic Evaluation of Eosinophilic Esophagitis in Pediatric Patients Presenting with Dysphagia or Abdominal Pain and Comparison of the Histology between the Two Groups. Canadian Journal of Gastroenterology and Hepatology. 2017. Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1141403
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1141403