Labelling of 90Y- and 177Lu-DOTA-Bioconjugates for Targeted Radionuclide Therapy: A Comparison among Manual, Semiautomated, and Fully Automated Synthesis

Joint Authors

Fioroni, F.
Grassi, E.
Iori, Michele
Capponi, Pier C.
Rubagotti, Sara
Esposizione, Luca Rosario
Seemann, Johanna
Pitzschler, Riccardo
Dreger, Thorsten
Formisano, Debora
Versari, A.
Asti, M.

Source

Contrast Media & Molecular Imaging

Issue

Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-12, 12 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2017-05-25

Country of Publication

Egypt

No. of Pages

12

Main Subjects

Diseases
Medicine

Abstract EN

In spite of the hazard due to the radiation exposure, preparation of 90Y- and 177Lu-labelled radiopharmaceuticals is still mainly performed using manual procedures.

In the present study the performance of a commercial automatic synthesizer based on disposable cassettes for the labelling of 177Lu- and 90Y-DOTA-conjugated biomolecules (namely, DOTATOC and PSMA-617) was evaluated and compared to a manual and a semiautomated approach.

The dose exposure of the operators was evaluated as well.

More than 300 clinical preparations of both 90Y- and 177Lu-labelled radiopharmaceuticals have been performed using the three different methods.

The mean radiochemical yields for 90Y-DOTATOC were 96.2±4.9%, 90.3±5.6%, and 82.0±8.4%, while for 177Lu-DOTATOC they were 98.3% ± 0.6, 90.8% ± 8.3, and 83.1±5.7% when manual, semiautomated, and automated approaches were used, respectively.

The mean doses on the whole hands for yttrium-90 preparations were 0.15±0.4 mSv/GBq, 0.04±0.1 mSv/GBq, and 0.11±0.3 mSv/GBq for manual, semiautomated, and automated synthesis, respectively, and for lutetium-177 preparations, they were 0.02±0.008 mSv/GBq, 0.01±0.03 mSv/GBq, and 0.01±0.02 mSv/GBq, respectively.

In conclusion, the automated approach guaranteed reliable and reproducible preparations of pharmaceutical grade therapeutic radiopharmaceuticals in a decent RCY.

The radiation exposure of the operators remained comparable to the manual approach mainly due to the fact that a dedicated shielding was still not available for the system.

American Psychological Association (APA)

Iori, Michele& Capponi, Pier C.& Rubagotti, Sara& Esposizione, Luca Rosario& Seemann, Johanna& Pitzschler, Riccardo…[et al.]. 2017. Labelling of 90Y- and 177Lu-DOTA-Bioconjugates for Targeted Radionuclide Therapy: A Comparison among Manual, Semiautomated, and Fully Automated Synthesis. Contrast Media & Molecular Imaging،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1141852

Modern Language Association (MLA)

Iori, Michele…[et al.]. Labelling of 90Y- and 177Lu-DOTA-Bioconjugates for Targeted Radionuclide Therapy: A Comparison among Manual, Semiautomated, and Fully Automated Synthesis. Contrast Media & Molecular Imaging No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1141852

American Medical Association (AMA)

Iori, Michele& Capponi, Pier C.& Rubagotti, Sara& Esposizione, Luca Rosario& Seemann, Johanna& Pitzschler, Riccardo…[et al.]. Labelling of 90Y- and 177Lu-DOTA-Bioconjugates for Targeted Radionuclide Therapy: A Comparison among Manual, Semiautomated, and Fully Automated Synthesis. Contrast Media & Molecular Imaging. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1141852

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1141852