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A Large PROP1 Gene Deletion in a Turkish Pedigree
Joint Authors
Görar, Süheyla
Turkkahraman, Doga
Yararbas, Kanay
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-14
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Pituitary-specific paired-like homeodomain transcription factor, PROP1, is associated with multiple pituitary hormone deficiency.
Alteration of the gene encoding the PROP1 may affect somatotropes, thyrotropes, and lactotropes, as well as gonadotropes and corticotropes.
We performed genetic analysis of PROP1 gene in a Turkish pedigree with three siblings who presented with short stature.
Parents were first degree cousins.
Index case, a boy, had somatotrope, gonadotrope, thyrotrope, and corticotrope deficiency.
However, two elder sisters had somatotroph, gonadotroph, and thyrotroph deficiency and no corticotroph deficiency.
On pituitary magnetic resonance, partial empty sella was detected with normal bright spot in all siblings.
In genetic analysis, we found a gross deletion involving PROP1 coding region.
In conclusion, we report three Turkish siblings with a gross deletion in PROP1 gene.
Interestingly, although little boy with combined pituitary hormone deficiency has adrenocorticotropic hormone (ACTH) deficiency, his elder sisters with the same gross PROP1 deletion have no ACTH deficiency.
This finding is in line with the fact that patients with PROP1 mutations may have different phenotype/genotype correlation.
American Psychological Association (APA)
Görar, Süheyla& Turkkahraman, Doga& Yararbas, Kanay. 2018. A Large PROP1 Gene Deletion in a Turkish Pedigree. Case Reports in Endocrinology،Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1142918
Modern Language Association (MLA)
Görar, Süheyla…[et al.]. A Large PROP1 Gene Deletion in a Turkish Pedigree. Case Reports in Endocrinology No. 2018 (2018), pp.1-5.
https://search.emarefa.net/detail/BIM-1142918
American Medical Association (AMA)
Görar, Süheyla& Turkkahraman, Doga& Yararbas, Kanay. A Large PROP1 Gene Deletion in a Turkish Pedigree. Case Reports in Endocrinology. 2018. Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1142918
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1142918