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Superficial Myofibroblastoma in the Vulva Mimicking Aggressive Angiomyxoma: A Case Report and Review of the Literature
Joint Authors
Peng, Wei-Xia
Wada, Ryuichi
Kure, Shoko
Fukunaga, Masaharu
Naito, Zenya
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-05-26
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Background: Superficial myofibroblastoma (SMF) is a very rare benign mesenchymal tumor in the female lower genital tract.
Only 46 cases have been reported in the English language literature, among which only 7 cases arose in the vulva.
Sometimes SMF histologically mimics aggressive angiomyxoma (AA) in which massive myxoid change in stroma is characteristic.
We herein report a case of vulvar SMF with prominent myxoid stroma and review the literature with the emphasis on the differential diagnosis of SMF and AA.
Case presentation: a 37-year-old woman presented with a painless mass in the vulva.
Magnetic resonance imaging (MRI) showed a well-circumscribed 7 cm mass in the subcutis of the vulva.
The tumor was resected.
Histopathologically, the tumor was characterized by sparsely populated spindle-shaped cells in the fibromyxoid stroma.
Thin-walled blood vessels were detected.
Mitoses or pleomorphism was not found.
Tumor cells were positive for vimentin, ER, PgR, and desmin.
Some cells were positive for alpha-SMA and CD34.
All cells were negative for S100 protein.
Conclusions: because SMF and AA show different clinical prognoses, distinguishing SMF from AA is important.
However, SMF may share many common histological features with AA: superficial localization (above fascia), sharp borderline from adjacent tissue, expansive growth pattern; a specific vascular pattern will lead to an accurate diagnosis of SMF.
Familiarization with the histological characteristics of the two entities will help to make a prognostic prediction.
American Psychological Association (APA)
Peng, Wei-Xia& Wada, Ryuichi& Kure, Shoko& Fukunaga, Masaharu& Naito, Zenya. 2019. Superficial Myofibroblastoma in the Vulva Mimicking Aggressive Angiomyxoma: A Case Report and Review of the Literature. Case Reports in Pathology،Vol. 2019, no. 2019, pp.1-5.
https://search.emarefa.net/detail/BIM-1143381
Modern Language Association (MLA)
Peng, Wei-Xia…[et al.]. Superficial Myofibroblastoma in the Vulva Mimicking Aggressive Angiomyxoma: A Case Report and Review of the Literature. Case Reports in Pathology No. 2019 (2019), pp.1-5.
https://search.emarefa.net/detail/BIM-1143381
American Medical Association (AMA)
Peng, Wei-Xia& Wada, Ryuichi& Kure, Shoko& Fukunaga, Masaharu& Naito, Zenya. Superficial Myofibroblastoma in the Vulva Mimicking Aggressive Angiomyxoma: A Case Report and Review of the Literature. Case Reports in Pathology. 2019. Vol. 2019, no. 2019, pp.1-5.
https://search.emarefa.net/detail/BIM-1143381
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1143381