Ibrutinib Treatment through Nasogastric Tube in a Comatose Patient with Central Nervous System Localization of Mantle Cell Lymphoma
Joint Authors
Alsuliman, Tamim
Belghoul, Maifa
Choufi, Bachra
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-3, 3 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-08-16
Country of Publication
Egypt
No. of Pages
3
Main Subjects
Abstract EN
Nowadays, mantle cell lymphoma is considered to have one of the worst prognostic profiles among lymphoid malignancies.
Mantle cell lymphoma rarely affects the central nervous system (CNS) as it represents about 0.9% of diagnosis and 4% among recurrent cases.
Here, we present the case of a 69-year-old male patient who was diagnosed with mantle cell lymphoma in 2006.
The patient relapsed three times, without affecting the CNS, then was treated accordingly, and achieved complete remission three times.
Four years after his last complete remission, upon receiving his last dose of treatment, the medical team noted a rapid worsening of the patient’s neurological status followed by a deep coma state causing MCL neurological recurrence by exclusion diagnosis.
The patient then received ibrutinib via a nasogastric tube at a dose of 560 mg daily.
Two days after receiving his last dose of ibrutinib, the patient regained full consciousness, and 10 days later, he was discharged from the hospital.
The patient achieved complete remission and showed no signs of neurological damages for 24 months following his ibrutinib treatment.
We believe that the administration of ibrutinib through the nasogastric tube was a determinant factor in this patient’s remission and survival.
American Psychological Association (APA)
Alsuliman, Tamim& Belghoul, Maifa& Choufi, Bachra. 2018. Ibrutinib Treatment through Nasogastric Tube in a Comatose Patient with Central Nervous System Localization of Mantle Cell Lymphoma. Case Reports in Hematology،Vol. 2018, no. 2018, pp.1-3.
https://search.emarefa.net/detail/BIM-1143899
Modern Language Association (MLA)
Alsuliman, Tamim…[et al.]. Ibrutinib Treatment through Nasogastric Tube in a Comatose Patient with Central Nervous System Localization of Mantle Cell Lymphoma. Case Reports in Hematology No. 2018 (2018), pp.1-3.
https://search.emarefa.net/detail/BIM-1143899
American Medical Association (AMA)
Alsuliman, Tamim& Belghoul, Maifa& Choufi, Bachra. Ibrutinib Treatment through Nasogastric Tube in a Comatose Patient with Central Nervous System Localization of Mantle Cell Lymphoma. Case Reports in Hematology. 2018. Vol. 2018, no. 2018, pp.1-3.
https://search.emarefa.net/detail/BIM-1143899
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1143899