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A Case of Heparin-Induced Thrombocytopenia That Developed in the Therapeutic Course of Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
Joint Authors
Harada, Makoto
Ichikawa, Tohru
Kobayashi, Mamoru
Nonaka, Taketoshi
Sumi, Masahiko
Ishii, Wataru
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-07-22
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Background.
Heparin-induced thrombocytopenia (HIT) causes thrombocytopenia via an immunological mechanism, resulting in severe organ injury due to arterial-venous thrombosis.
HIT often develops in hemodialysis patients owing to heparin use.
Anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV) is a systemic vasculitis, and cases of AAV complicated with HIT are rare.
In addition, it mostly occurs in patients undergoing hemodialysis.
Case Presentation.
An 87-year-old woman presented with rapidly progressive renal failure and severe leg edema.
She was diagnosed with AAV and treated with glucocorticoid and heparin calcium to prevent deep vein thrombosis.
Eight days after the start of heparin calcium, her platelet count decreased and the anti-platelet factor 4-heparin complex antibody was strongly positive (>5.0 U/mL; the cutoff point of the anti-platelet factor 4-heparin complex antibody evaluated by the latex turbidity assay is 1.0 U/mL).
She was diagnosed with HIT and treated with argatroban.
Subsequently, her platelet counts increased gradually.
Conclusion.
We encountered a case of HIT that developed prior to the induction of hemodialysis in the clinical course of AAV.
When AAV clinical course presents thrombocytopenia, the possibility of HIT should be considered.
American Psychological Association (APA)
Nonaka, Taketoshi& Harada, Makoto& Sumi, Masahiko& Ishii, Wataru& Ichikawa, Tohru& Kobayashi, Mamoru. 2019. A Case of Heparin-Induced Thrombocytopenia That Developed in the Therapeutic Course of Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis. Case Reports in Rheumatology،Vol. 2019, no. 2019, pp.1-4.
https://search.emarefa.net/detail/BIM-1144201
Modern Language Association (MLA)
Nonaka, Taketoshi…[et al.]. A Case of Heparin-Induced Thrombocytopenia That Developed in the Therapeutic Course of Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis. Case Reports in Rheumatology No. 2019 (2019), pp.1-4.
https://search.emarefa.net/detail/BIM-1144201
American Medical Association (AMA)
Nonaka, Taketoshi& Harada, Makoto& Sumi, Masahiko& Ishii, Wataru& Ichikawa, Tohru& Kobayashi, Mamoru. A Case of Heparin-Induced Thrombocytopenia That Developed in the Therapeutic Course of Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis. Case Reports in Rheumatology. 2019. Vol. 2019, no. 2019, pp.1-4.
https://search.emarefa.net/detail/BIM-1144201
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1144201