Severely Disseminated Kaposi Sarcoma after ABO-Incompatible Kidney Transplantation Treated Successfully with Paclitaxel and Gemcitabine Combined with Hemodialysis
Joint Authors
Junker, Niels
Krarup-Hansen, Anders
Bomholt, Tobias
Egfjord, Martin
Sørensen, Søren Schwartz
Source
Case Reports in Transplantation
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-3, 3 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-12-11
Country of Publication
Egypt
No. of Pages
3
Main Subjects
Abstract EN
Kaposi Sarcoma (KS) is driven by human herpes virus 8 causing vascular proliferation which is induced by loss of immune function most often due to HIV or immunosuppressants.
KS occurs with increased incidence in kidney transplant recipients, but rarely is disseminated.
We report a 64-year-old male who developed severely disseminated KS 5 months after ABO-incompatible kidney-transplantation.
No guidelines for chemotherapy exist in this case and reduced kidney function and impaired immune system complicates the use of systemic chemotherapy in kidney transplant recipients.
A combination of paclitaxel and gemcitabine followed by two days of hemodialysis treatment was chosen since paclitaxel can be given in full dose independently of kidney function and gemcitabine is metabolised to 2′,2′-difluorodeoxyuridine which is found to be highly dialysable.
The present treatment was well tolerated by the patient with one episode of leukopenia and elevated alanine transaminase during treatment which resolved.
There were no serious adverse events and the patient obtained a complete remission verified by Positron Emission Tomography CT after ending chemotherapy and at one-year follow up.
American Psychological Association (APA)
Bomholt, Tobias& Krarup-Hansen, Anders& Egfjord, Martin& Sørensen, Søren Schwartz& Junker, Niels. 2019. Severely Disseminated Kaposi Sarcoma after ABO-Incompatible Kidney Transplantation Treated Successfully with Paclitaxel and Gemcitabine Combined with Hemodialysis. Case Reports in Transplantation،Vol. 2019, no. 2019, pp.1-3.
https://search.emarefa.net/detail/BIM-1145259
Modern Language Association (MLA)
Bomholt, Tobias…[et al.]. Severely Disseminated Kaposi Sarcoma after ABO-Incompatible Kidney Transplantation Treated Successfully with Paclitaxel and Gemcitabine Combined with Hemodialysis. Case Reports in Transplantation No. 2019 (2019), pp.1-3.
https://search.emarefa.net/detail/BIM-1145259
American Medical Association (AMA)
Bomholt, Tobias& Krarup-Hansen, Anders& Egfjord, Martin& Sørensen, Søren Schwartz& Junker, Niels. Severely Disseminated Kaposi Sarcoma after ABO-Incompatible Kidney Transplantation Treated Successfully with Paclitaxel and Gemcitabine Combined with Hemodialysis. Case Reports in Transplantation. 2019. Vol. 2019, no. 2019, pp.1-3.
https://search.emarefa.net/detail/BIM-1145259
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1145259