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Endocan, a Risk Factor for Developing Acute Respiratory Distress Syndrome among Severe Pneumonia Patients
Joint Authors
Ying, Jun
Zhou, Danfei
Gu, Tongjie
Huang, Jianda
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-04-01
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
Severe pneumonia (SP) has been widely accepted as a major cause for acute respiratory distress syndrome (ARDS), and the development of ARDS is significantly associated with increased mortality.
This study aimed to identify potential predictors for ARDS development in patients with SP.
Methods.
Eligible SP patients at admission from January 2013 to June 2017 were prospectively enrolled, and ARDS development within hospital stay was identified.
Risk factors for ARDS development in SP patients were analyzed by univariate and multivariate logistic regression analysis.
The receiver operating characteristic (ROC) curve analysis with the area under the curve (AUC) was performed for the predictive value of endocan for ARDS development.
Results.
A total of 145 SP patients were eventually enrolled into the final analysis, of which 37 developed ARDS during the hospital stay.
Our final multivariate logistic regression analysis suggested plasma endocan expression as the only independent risk factor for ARDS development in SP patients (OR: 1.57, 95% CI: 1.14–2.25, P=0.021).
ROC curve analysis of plasma endocan resulted in an AUC of 0.754, 95% CI of 0.642–0.866, a cutoff value of 11.6 ng/mL, a sensitivity of 78.7%, and a specificity of 70.3%, respectively (P<0.01).
Conclusions.
Endocan expression at ICU admission is a reliable predictive factor in predicting ARDS in patients with SP.
American Psychological Association (APA)
Ying, Jun& Zhou, Danfei& Gu, Tongjie& Huang, Jianda. 2019. Endocan, a Risk Factor for Developing Acute Respiratory Distress Syndrome among Severe Pneumonia Patients. Canadian Respiratory Journal،Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1145690
Modern Language Association (MLA)
Ying, Jun…[et al.]. Endocan, a Risk Factor for Developing Acute Respiratory Distress Syndrome among Severe Pneumonia Patients. Canadian Respiratory Journal No. 2019 (2019), pp.1-6.
https://search.emarefa.net/detail/BIM-1145690
American Medical Association (AMA)
Ying, Jun& Zhou, Danfei& Gu, Tongjie& Huang, Jianda. Endocan, a Risk Factor for Developing Acute Respiratory Distress Syndrome among Severe Pneumonia Patients. Canadian Respiratory Journal. 2019. Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1145690
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1145690