Bone Marrow-Liver-Spleen Type of Large B-Cell Lymphoma Associated with Hemophagocytic Syndrome: A Rare Aggressive Extranodal Lymphoma
Joint Authors
Chapman-Fredericks, Jennifer
Lyapichev, K.
Vega, Francisco
Iakymenko, Oleksii
Teomete, Uygar
Sanchez, Sandra Patricia
Ikpatt, Offiong Francis
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-08-01
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Recently, an unusual subtype of large B-cell lymphoma (LBCL) with distinctive clinicopathologic features has been recognized; it is characterized by involvement of bone marrow with or without liver and/or spleen, but no lymph node or other extranodal sites, usually associated with fever, anemia, and hemophagocytic lymphohistiocytosis (HLH).
Because of this distinctive clinical presentation, it has been designated “bone marrow-liver-spleen” (BLS) type of LBCL.
To date there is only one series of 11 cases of BLS type of LBCL with detailed clinical, pathologic, and cytogenetic data.
Herein, we describe a case of BLS type LBCL presenting with associated HLH in a 73-year-old female.
The bone marrow core biopsy showed cytologically atypical large lymphoma cells present in a scattered interstitial distribution and hemophagocytosis and infrequent large lymphoma cells were seen in the bone marrow aspirate smears.
Circulating lymphoma cells were not seen in the peripheral blood smears.
The patient underwent treatment with chemotherapy (R-CHOP) but unfortunately passed away 2 months after initial presentation.
BLS type of LBCL is a very rare and clinically aggressive lymphoma whose identification may be delayed by clinicians and hematopathologists due to its unusual clinical presentation and pathologic features.
American Psychological Association (APA)
Lyapichev, K.& Chapman-Fredericks, Jennifer& Iakymenko, Oleksii& Ikpatt, Offiong Francis& Teomete, Uygar& Sanchez, Sandra Patricia…[et al.]. 2017. Bone Marrow-Liver-Spleen Type of Large B-Cell Lymphoma Associated with Hemophagocytic Syndrome: A Rare Aggressive Extranodal Lymphoma. Case Reports in Hematology،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1146033
Modern Language Association (MLA)
Lyapichev, K.…[et al.]. Bone Marrow-Liver-Spleen Type of Large B-Cell Lymphoma Associated with Hemophagocytic Syndrome: A Rare Aggressive Extranodal Lymphoma. Case Reports in Hematology No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1146033
American Medical Association (AMA)
Lyapichev, K.& Chapman-Fredericks, Jennifer& Iakymenko, Oleksii& Ikpatt, Offiong Francis& Teomete, Uygar& Sanchez, Sandra Patricia…[et al.]. Bone Marrow-Liver-Spleen Type of Large B-Cell Lymphoma Associated with Hemophagocytic Syndrome: A Rare Aggressive Extranodal Lymphoma. Case Reports in Hematology. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1146033
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1146033