Effects of Ivabradine on Residual Myocardial Ischemia after PCI Evaluated by Stress Echocardiography
Joint Authors
Fedele, Francesco
Mancone, Massimo
Sardella, Gennaro
Maestrini, Viviana
Infusino, Fabio
Calcagno, Simone
Dettori, Olga
Taccheri, Temistocle
Bruno, Pasqualina
Source
Cardiology Research and Practice
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-04-01
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
Residual angina after PCI is a frequently occurring disease.
Ivabradine improves symptoms but its role in patients without left ventricular systolic dysfunction is still unclear.
The aim was to quantify the effects of ivabradine in terms of MVO2 indicators and diastolic function.
Methods.
Twenty-eight consecutive patients with residual angina after PCI were randomized to ivabradine 5 mg twice/day (IG) or standard therapy (CG).
All patients performed a stress echocardiography at the enrollment and after 30 days.
MVO2 was estimated from double product (DP) and triple product (TP) integrating DP with ejection time (ET).
Diastolic function was evaluated determining E and A waves, E′ measurements, and E/E′ ratio both at rest and at the peak of exercise.
Results.
The exercise time was longer in IG 9′49″ ± 48″ vs 8′09″ ± 59″ in CG (p=0.0001), reaching a greater workload (IG 139.3 ± 13.4 vs CG 118.7 ± 19.6 Watts; p=0.003).
MVO2 expressed with DP and TP was significantly higher in IG (DP: IG 24194 ± 2697 vs CG 20358 ± 4671.8, p=0.01; TP: IG 17239 ± 4710 vs CG 12206 ± 4413, p=0.007).
At peak exercise, the ET was diminished in IG than CG.
The analysis of diastolic function after the exercise revealed an increase of E and A waves, without difference in the E/A ratio.
The E′ wave was higher in IG than CG, and in the same group, the differences between baseline and peak exercise were greater (∆E′3.14 ± 0.7 vs 2.4 ± 1.13, p=0.047).
The E/E′ ratio was reduced in patients treated with ivabradine (IG 10.2 ± 2.0 vs CG 7.9 ± 1.6, p=0.002).
Conclusions.
Ivabradine seems to produce a significant improvement of ischemic threshold, chronotropic reserve, and diastolic function.
American Psychological Association (APA)
Calcagno, Simone& Infusino, Fabio& Dettori, Olga& Taccheri, Temistocle& Bruno, Pasqualina& Maestrini, Viviana…[et al.]. 2019. Effects of Ivabradine on Residual Myocardial Ischemia after PCI Evaluated by Stress Echocardiography. Cardiology Research and Practice،Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1146127
Modern Language Association (MLA)
Calcagno, Simone…[et al.]. Effects of Ivabradine on Residual Myocardial Ischemia after PCI Evaluated by Stress Echocardiography. Cardiology Research and Practice No. 2019 (2019), pp.1-7.
https://search.emarefa.net/detail/BIM-1146127
American Medical Association (AMA)
Calcagno, Simone& Infusino, Fabio& Dettori, Olga& Taccheri, Temistocle& Bruno, Pasqualina& Maestrini, Viviana…[et al.]. Effects of Ivabradine on Residual Myocardial Ischemia after PCI Evaluated by Stress Echocardiography. Cardiology Research and Practice. 2019. Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1146127
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1146127