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Life-Threatening Intrapulmonary Hemorrhage due to Vancomycin-Induced Thrombocytopenia: A Case Report
Joint Authors
Abdalhadi, Haneen
Fahmawi, Yazan
Das, Abhijin
Fouty, Brian
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-3, 3 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-09-30
Country of Publication
Egypt
No. of Pages
3
Main Subjects
Abstract EN
Thrombocytopenia is a rare and sometimes life-threatening complication of Vancomycin.
A 52-year-old male patient with acute kidney injury was treated with Vancomycin for ventilator-associated pneumonia.
Three days later, his platelets decreased from 172×109/L to 3×109/L over a 36-hour period.
The patient developed significant intrapulmonary bleeding leading to profound hypoxemia.
Workup was negative for thrombotic thrombocytopenic purpura, disseminated intravascular coagulopathy, atypical hemolytic uremic syndrome, heparin-induced thrombocytopenia, and autoimmune diseases.
All recently started medications were discontinued, and the patient was started empirically on methylprednisolone and intravenous immunoglobulin.
The patient’s platelets increased, and his airway bleeding stopped within 48 hours; his platelet count returned to normal by 18 days.
Vancomycin-dependent anti-platelet antibodies were identified in the patient’s serum by flow cytometry.
Thrombocytopenia is an underrecognized complication of Vancomycin that can lead to life-threating bleeding.
Stopping Vancomycin may be sufficient to reverse the thrombocytopenia in patients with normal renal function, but more aggressive measures such as steroids, IVIG, and dialysis may be required to stop bleeding and reverse thrombocytopenia in patients with underlying kidney injury who cannot effectively excrete Vancomycin.
American Psychological Association (APA)
Abdalhadi, Haneen& Fahmawi, Yazan& Das, Abhijin& Fouty, Brian. 2020. Life-Threatening Intrapulmonary Hemorrhage due to Vancomycin-Induced Thrombocytopenia: A Case Report. Case Reports in Critical Care،Vol. 2020, no. 2020, pp.1-3.
https://search.emarefa.net/detail/BIM-1146354
Modern Language Association (MLA)
Abdalhadi, Haneen…[et al.]. Life-Threatening Intrapulmonary Hemorrhage due to Vancomycin-Induced Thrombocytopenia: A Case Report. Case Reports in Critical Care No. 2020 (2020), pp.1-3.
https://search.emarefa.net/detail/BIM-1146354
American Medical Association (AMA)
Abdalhadi, Haneen& Fahmawi, Yazan& Das, Abhijin& Fouty, Brian. Life-Threatening Intrapulmonary Hemorrhage due to Vancomycin-Induced Thrombocytopenia: A Case Report. Case Reports in Critical Care. 2020. Vol. 2020, no. 2020, pp.1-3.
https://search.emarefa.net/detail/BIM-1146354
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1146354