A Case of Spontaneously Improving Secondary Hemophagocytic Lymphohistiocytosis in an Adult Associated with T-Cell Histiocyte-Rich Large B-Cell Lymphoma
Joint Authors
Burris, Ashley
Askin, Cyrus
Layman, Clifton
Haney, Brian
Hall, Jordan
Source
Case Reports in Oncological Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-02-22
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Secondary hemophagocytic lymphohistiocytosis (HLH) in adults is a rare, often fatal syndrome characterized by widespread immune dysregulation.
It is seen as a complication of infections, autoimmune diseases, and malignancies.
Among the malignancy-related causes, aggressive T-cell or NK-cell neoplasms are most notable, while B-cell lymphomas are less commonly implicated.
We present the case of a 32-year-old male transferred to our facility with concern for HLH.
During the first week of his hospitalization, his diagnosis was confirmed and the patient demonstrated spontaneous improvement in his symptoms prompting us to delay therapy while searching for a primary cause.
In the second week, the patient deteriorated, leading us to initiate steroid monotherapy in the absence of a cause for his HLH.
Meanwhile, pathology results from an excisional lymph node biopsy confirmed a diagnosis of T-cell/histiocyte-rich large B-cell lymphoma (TCHRLBCL).
Subsequently, we initiated therapy with dose-adjusted R-EPOCH.
The patient achieved a complete remission of both HLH and TCHRLBCL as well as a complete return to his prior functional status.
In our review of the literature, this represents only the second documented case of HLH associated with TCHRLBCL and the only documented case of an adult experiencing significant spontaneous recovery in this context.
American Psychological Association (APA)
Askin, Cyrus& Burris, Ashley& Layman, Clifton& Haney, Brian& Hall, Jordan. 2018. A Case of Spontaneously Improving Secondary Hemophagocytic Lymphohistiocytosis in an Adult Associated with T-Cell Histiocyte-Rich Large B-Cell Lymphoma. Case Reports in Oncological Medicine،Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1146597
Modern Language Association (MLA)
Askin, Cyrus…[et al.]. A Case of Spontaneously Improving Secondary Hemophagocytic Lymphohistiocytosis in an Adult Associated with T-Cell Histiocyte-Rich Large B-Cell Lymphoma. Case Reports in Oncological Medicine No. 2018 (2018), pp.1-5.
https://search.emarefa.net/detail/BIM-1146597
American Medical Association (AMA)
Askin, Cyrus& Burris, Ashley& Layman, Clifton& Haney, Brian& Hall, Jordan. A Case of Spontaneously Improving Secondary Hemophagocytic Lymphohistiocytosis in an Adult Associated with T-Cell Histiocyte-Rich Large B-Cell Lymphoma. Case Reports in Oncological Medicine. 2018. Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1146597
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1146597