Primary Aldosteronism Associated with Multiple Adrenocortical Micronodules in a Patient with Renal Cell Carcinoma
Joint Authors
Sasano, Hironobu
Oba, Kazuhito
Chiba, Yuko
Matsuda, Yoko
Kumakawa, Takeshi
Aoyama, Rie
Akahoshi, Miho
Hashimoto, Seiji
Tachibana, Aya
Toyoshima, Koichi
Kodera, Remi
Toyoshima, Kenji
Tamura, Yoshiaki
Nagata, Takashi
Yamazaki, Yuto
Araki, Atsushi
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-02-24
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
A 47-year-old woman with a history of diabetes mellitus (DM) and obesity was admitted to our hospital for glucose control.
She was detected to have hypertension (HT) and diagnosed with primary aldosteronism (PA) based on the high level of aldosterone to renin ratio and the results of the upright furosemide-loading test according to the criteria of the Japanese Society of Hypertension (JSH) guidelines.
Computed tomography revealed left renal tumor and adrenocortical adenoma.
She underwent left nephrectomy and adrenalectomy.
The pathological findings were clear-cell renal cell carcinoma (RCC) and nonfunctional adrenocortical adenoma.
Her nonneoplastic adrenal tissue histologically revealed CYP11B2-positive multiple adrenocortical micronodules (MNs) and concomitant paradoxical hyperplasia of the zona glomerulosa.
Therefore, MNs were thought to be responsible for PA in this patient.
After surgery, HT was improved, and the result of upright furosemide-loading test after 12 months of surgery did not fulfill the criteria of PA according to the JSH guidelines.
However, the adrenocorticotrophic hormone stimulation test was positive; considering the possibility of slight aldosterone overproduction from the right adrenal gland, the administration of spironolactone was started.
Herein, we report a rare case of RCC in conjunction with PA histologically associated with MNs.
American Psychological Association (APA)
Oba, Kazuhito& Chiba, Yuko& Matsuda, Yoko& Kumakawa, Takeshi& Aoyama, Rie& Akahoshi, Miho…[et al.]. 2020. Primary Aldosteronism Associated with Multiple Adrenocortical Micronodules in a Patient with Renal Cell Carcinoma. Case Reports in Endocrinology،Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1146999
Modern Language Association (MLA)
Oba, Kazuhito…[et al.]. Primary Aldosteronism Associated with Multiple Adrenocortical Micronodules in a Patient with Renal Cell Carcinoma. Case Reports in Endocrinology No. 2020 (2020), pp.1-6.
https://search.emarefa.net/detail/BIM-1146999
American Medical Association (AMA)
Oba, Kazuhito& Chiba, Yuko& Matsuda, Yoko& Kumakawa, Takeshi& Aoyama, Rie& Akahoshi, Miho…[et al.]. Primary Aldosteronism Associated with Multiple Adrenocortical Micronodules in a Patient with Renal Cell Carcinoma. Case Reports in Endocrinology. 2020. Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1146999
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1146999