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Significance of Serum p53 Antibody as a Tumor Marker in Colorectal Cancer
Joint Authors
Sakamoto, Kazuhiro
Takahashi, Rina
Sugimoto, Kiichi
Motegi, Shunsuke
Tsukamoto, Ryoichi
Ichikawa, Ryosuke
Okazawa, Yu
Aoki, Jun
Takahashi, Makoto
Kojima, Yutaka
Okuzawa, Atsushi
Tomiki, Yuichi
Matsuoka, Joe
Ishiyama, Shun
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-12-16
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Objective.
We examined serum anti-p53 antibodies (S-p53Ab) in colorectal cancer.
Specifically, we retrospectively investigated the use of S-p53Ab as a prognostic marker after surgery for colorectal cancer.
Materials and Methods.
The levels of S-p53Ab, carcinoembryonic antigen (CEA), and carbohydrate antigen 19-9 (CA19-9) were measured in 160 colorectal cancer patients who underwent surgical treatment.
The rate of postoperative change (RPC) in the S-p53Ab titer was calculated as [subsequent antibody titer-lowest titer]/lowest titer.
Results.
A relationship between recurrence and RPC in the S-p53Ab titer was not observed in patients who tested negative for S-p53Ab preoperatively.
In addition, no patients, who tested negative for S-p53Ab preoperatively, tested positive for S-p53Ab at the follow-up after surgery.
Of the patients who tested positive for S-p53Ab preoperatively, those recurrences had a significantly higher RPC compared with those who did not (p<0.001).
Conclusions.
Although S-p53Ab is not a significant tumor marker in patients who test negative preoperatively, increases in the S-p53Ab titer should be continuously monitored and measured in patients who are positive for this antibody preoperatively, regardless of whether they later test negative.
American Psychological Association (APA)
Takahashi, Rina& Sakamoto, Kazuhiro& Sugimoto, Kiichi& Motegi, Shunsuke& Tsukamoto, Ryoichi& Ichikawa, Ryosuke…[et al.]. 2019. Significance of Serum p53 Antibody as a Tumor Marker in Colorectal Cancer. Disease Markers،Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1147000
Modern Language Association (MLA)
Takahashi, Rina…[et al.]. Significance of Serum p53 Antibody as a Tumor Marker in Colorectal Cancer. Disease Markers No. 2019 (2019), pp.1-6.
https://search.emarefa.net/detail/BIM-1147000
American Medical Association (AMA)
Takahashi, Rina& Sakamoto, Kazuhiro& Sugimoto, Kiichi& Motegi, Shunsuke& Tsukamoto, Ryoichi& Ichikawa, Ryosuke…[et al.]. Significance of Serum p53 Antibody as a Tumor Marker in Colorectal Cancer. Disease Markers. 2019. Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1147000
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1147000