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Severity of Vitamin D Deficiency Predicts Mortality in Ischemic Stroke Patients
Joint Authors
Owczarek, Aleksander
Olszanecka-Glinianowicz, Magdalena
Wajda, Jarosław
Świat, Maciej
Chudek, Jerzy
Brzozowska, Aniceta
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-05-02
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Background.
Vitamin D (VD) deficiency is considered an independent risk factor for death due to cardiovascular events including ischemic stroke (IS).
We assessed the hypothesis that decreased levels of 25-hydroxyvitamin D (25-OH-D) are associated with increased risk of mortality in patients with IS.
Methods.
Serum 25-OH-D, intact parathyroid hormone (iPTH), and intact fibroblast growth factor 23 (iFGF23) levels were assessed in serum of 240 consecutive patients admitted within the 24 hours after the onset of IS.
Mortality data was obtained from the local registry office.
Results.
Only three subjects (1.3%) had an optimal 25-OH-D level (30-80 ng/mL), 25 (10.4%) had a mildly reduced (insufficient) level, 61 (25.4%) had moderate deficiency, and 151 (62.9%) had a severe VD deficiency.
20% subjects had secondary hyperparathyroidism.
The serum 25-OH-D level was significantly lower than that in 480 matched subjects (9.9±7.1 vs.
21.0±8.7 ng/mL).
Of all the patients, 79 (32.9%) died during follow-up observation (44.9 months).
The mortality rates (per year) were 4.81 and 1.89 in a group with and without severe VD deficiency, respectively (incidence rate ratio: 2.52; 95% CI: 1.44–4.68).
There was no effect of secondary hyperparathyroidism and iFGF23 levels on mortality rates.
Age, 25−OH−D<10 ng/mL, and functional status (modified Rankin scale) were significant factors increasing the risk of death in multivariable Cox proportional hazard regression test.
Conclusions.
Severe VD deficiency is an emerging, strong negative predictor for survival after IS, independent of age and functional status.
VD supplementation in IS survivals may be considered due to high prevalence of its deficiency.
However, it is uncertain whether it will improve their survival.
American Psychological Association (APA)
Wajda, Jarosław& Świat, Maciej& Owczarek, Aleksander& Brzozowska, Aniceta& Olszanecka-Glinianowicz, Magdalena& Chudek, Jerzy. 2019. Severity of Vitamin D Deficiency Predicts Mortality in Ischemic Stroke Patients. Disease Markers،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1147078
Modern Language Association (MLA)
Wajda, Jarosław…[et al.]. Severity of Vitamin D Deficiency Predicts Mortality in Ischemic Stroke Patients. Disease Markers No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1147078
American Medical Association (AMA)
Wajda, Jarosław& Świat, Maciej& Owczarek, Aleksander& Brzozowska, Aniceta& Olszanecka-Glinianowicz, Magdalena& Chudek, Jerzy. Severity of Vitamin D Deficiency Predicts Mortality in Ischemic Stroke Patients. Disease Markers. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1147078
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1147078