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A Patient with Non-Hodgkin Lymphoma and Nonspecific Interstitial Pneumonia during Ibrutinib Therapy
Joint Authors
Jungmann, Sven
Ludwig, Wolf-Dieter
Blum, Torsten-Gerriet
Großwendt, Claudia
Boch, Christian
Rehbock, Beate
Griff, Sergej
Schmittel, Alexander
Bauer, Torsten T.
Schönfeld, Nicolas
Source
Case Reports in Oncological Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-11-10
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
We present a 74-year-old male with nonspecific interstitial pneumonia (NSIP) during treatment with ibrutinib for mantle cell lymphoma.
Previously, the patient had received six cycles of bendamustine and rituximab and six cycles of R-CHOP, followed by rituximab maintenance therapy.
Respiratory tract complications of ibrutinib other than infectious pneumonia have not been mentioned in larger trials, but individual case reports hinted to a possible association with the development of pneumonitis.
In our patient, the onset of alveolitis that progressed towards NSIP together with the onset of ibrutinib treatment suggests causality.
One week after ibrutinib was discontinued, nasal symptoms resolved first.
A follow-up CT showed a reduction in the reticular hyperdensities and ground-glass opacities, suggestive of restitution of the lung disease.
To our knowledge, this is the first case showing a strong link between ibrutinib and interstitial lung disease, strengthening a previous report on subacute pneumonitis.
Our findings have clinical implications because pulmonary side effects were reversible at this early stage.
We, therefore, suggest close monitoring for respiratory side effects in patients receiving ibrutinib.
American Psychological Association (APA)
Jungmann, Sven& Ludwig, Wolf-Dieter& Schönfeld, Nicolas& Blum, Torsten-Gerriet& Großwendt, Claudia& Boch, Christian…[et al.]. 2017. A Patient with Non-Hodgkin Lymphoma and Nonspecific Interstitial Pneumonia during Ibrutinib Therapy. Case Reports in Oncological Medicine،Vol. 2017, no. 2017, pp.1-4.
https://search.emarefa.net/detail/BIM-1147759
Modern Language Association (MLA)
Jungmann, Sven…[et al.]. A Patient with Non-Hodgkin Lymphoma and Nonspecific Interstitial Pneumonia during Ibrutinib Therapy. Case Reports in Oncological Medicine No. 2017 (2017), pp.1-4.
https://search.emarefa.net/detail/BIM-1147759
American Medical Association (AMA)
Jungmann, Sven& Ludwig, Wolf-Dieter& Schönfeld, Nicolas& Blum, Torsten-Gerriet& Großwendt, Claudia& Boch, Christian…[et al.]. A Patient with Non-Hodgkin Lymphoma and Nonspecific Interstitial Pneumonia during Ibrutinib Therapy. Case Reports in Oncological Medicine. 2017. Vol. 2017, no. 2017, pp.1-4.
https://search.emarefa.net/detail/BIM-1147759
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1147759