Lenalidomide-Associated Immune Thrombocytopenia: A Case Report and Review of the Literature
Joint Authors
Forehand III, William
Ajebo, Germame
Toscano, Michael
Jillella, Anand
Dainer, Paul
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-11-12
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Lenalidomide is indicated in the front-line management of multiple myeloma.
More recently, it has been introduced for use in treating other hematologic malignancies.
Although the drug is known to cause myelosuppression, there have been rare reports of lenalidomide-associated immune thrombocytopenia (ITP).
Here, we review the literature on lenalidomide-associated ITP and report upon a 59-year-old man who was administered lenalidomide due to concern of progressive multiple myeloma more than a year following his having undergone an autologous hematopoietic stem cell transplant.
His platelet count precipitously declined and lead to his hospitalization.
Despite our withholding of the drug, he did not respond to platelet transfusions or administration of corticosteroids.
He was successfully managed with intermittent immune globulin for several months before definitive treatment with splenectomy, which resulted in the complete resolution of his thrombocytopenia.
A literature search identified a total of six additional cases of lenalidomide-associated ITP.
Similarly, many of the reported cases were associated with persistent thrombocytopenia after discontinuation of the drug.
Furthermore, these patients were generally managed successfully with standard ITP therapies, such as corticosteroids or intravenous immune globulin.
American Psychological Association (APA)
Forehand III, William& Ajebo, Germame& Toscano, Michael& Jillella, Anand& Dainer, Paul. 2020. Lenalidomide-Associated Immune Thrombocytopenia: A Case Report and Review of the Literature. Case Reports in Hematology،Vol. 2020, no. 2020, pp.1-5.
https://search.emarefa.net/detail/BIM-1147808
Modern Language Association (MLA)
Forehand III, William…[et al.]. Lenalidomide-Associated Immune Thrombocytopenia: A Case Report and Review of the Literature. Case Reports in Hematology No. 2020 (2020), pp.1-5.
https://search.emarefa.net/detail/BIM-1147808
American Medical Association (AMA)
Forehand III, William& Ajebo, Germame& Toscano, Michael& Jillella, Anand& Dainer, Paul. Lenalidomide-Associated Immune Thrombocytopenia: A Case Report and Review of the Literature. Case Reports in Hematology. 2020. Vol. 2020, no. 2020, pp.1-5.
https://search.emarefa.net/detail/BIM-1147808
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1147808