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An Aggressive Form of Langerhan Cell Histiocytosis in an Adult: Therapeutic Challenges
Joint Authors
Seegobin, Karan
Maharaj, Satish
Baldeo, Cherisse
Shukri, Amal
Rana, Fauzia
Source
Case Reports in Oncological Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-3, 3 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-12-03
Country of Publication
Egypt
No. of Pages
3
Main Subjects
Abstract EN
Langerhans cell histiocytosis (LCH) is rare in adults.
Regular follow-up is mandatory due to reoccurrence.
A 35-year-old male with an incidental left iliac bone lesion was diagnosed with LCH.
He later became symptomatic with hip pain and spread of the disease.
Despite excision of the symptomatic iliac lesion, he had progression while on cytarabine and nivolumab, evidenced by increased bone pain and involvement of other bones on imaging.
He underwent excision of the jaw lesion followed by vinblastine; he was pain free and had stable disease on PET imaging after 3 months.
LCH is an uncommon neoplasia.
Treatment is reserved for symptomatic patients while asymptomatic patients are observed.
Follow-up is imperative due to the risk of reoccurrence.
Despite surgical treatment together with one of the front-line agents for refractory disease, in this case cytarabine, he still had progression of the disease.
Furthermore, the trial of nivolumab was of no benefit.
This case highlights good response to vinblastine which is previously reported to have good success.
No trials are published, and the optimal strategy has yet to be defined.
LCH with multiple bony involvement can be aggressive and therapeutically challenging.
American Psychological Association (APA)
Seegobin, Karan& Maharaj, Satish& Baldeo, Cherisse& Shukri, Amal& Rana, Fauzia. 2017. An Aggressive Form of Langerhan Cell Histiocytosis in an Adult: Therapeutic Challenges. Case Reports in Oncological Medicine،Vol. 2017, no. 2017, pp.1-3.
https://search.emarefa.net/detail/BIM-1147891
Modern Language Association (MLA)
Seegobin, Karan…[et al.]. An Aggressive Form of Langerhan Cell Histiocytosis in an Adult: Therapeutic Challenges. Case Reports in Oncological Medicine No. 2017 (2017), pp.1-3.
https://search.emarefa.net/detail/BIM-1147891
American Medical Association (AMA)
Seegobin, Karan& Maharaj, Satish& Baldeo, Cherisse& Shukri, Amal& Rana, Fauzia. An Aggressive Form of Langerhan Cell Histiocytosis in an Adult: Therapeutic Challenges. Case Reports in Oncological Medicine. 2017. Vol. 2017, no. 2017, pp.1-3.
https://search.emarefa.net/detail/BIM-1147891
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1147891