Treatment of Recurrent Clostridium difficile Infection in an Immunocompromised Patient with Severe Neutropenia Not Responding to Standard Therapy
Joint Authors
AlQahtani, Hajar
Baloch, Saeed
Tabb, Deanne
Source
Case Reports in Infectious Diseases
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-02-26
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
One of the most effective strategies in reducing the risk of Clostridium difficile infection (CDI) recurrence is fecal microbiota transplantation (FMT).
However, several adverse events have been reported post FMT, and data on the efficacy and safety of FMT in immunocompromised patients with hematological malignancies are rare.
This report presents FMT treatment for refractory CDI in a severely immunocompromised patient.
A 69-year-old female presented to the emergency department complaining of foul smelling, intractable, watery diarrhea and generalized abdominal pain.
She was recently diagnosed with high-risk myelodysplastic Syndrome (MDS) requiring daily blood transfusions and reported multiple CDI episodes in the past treated successfully with metronidazole and vancomycin as mono- or combotherapy.
During this admission, treatment with oral vancomycin (high dose) and intravenous metronidazole was unsuccessful, so FMT was administered.
The patient recovered well despite an absolute neutrophil count (ANC) < 0.25 × 109/L, and chemotherapy was initiated soon after.
FMT was successful and safe in this patient, with no relapse and adverse events seen in 8 weeks of follow-up via phone calls and office visits.
American Psychological Association (APA)
AlQahtani, Hajar& Baloch, Saeed& Tabb, Deanne. 2020. Treatment of Recurrent Clostridium difficile Infection in an Immunocompromised Patient with Severe Neutropenia Not Responding to Standard Therapy. Case Reports in Infectious Diseases،Vol. 2020, no. 2020, pp.1-4.
https://search.emarefa.net/detail/BIM-1148131
Modern Language Association (MLA)
AlQahtani, Hajar…[et al.]. Treatment of Recurrent Clostridium difficile Infection in an Immunocompromised Patient with Severe Neutropenia Not Responding to Standard Therapy. Case Reports in Infectious Diseases No. 2020 (2020), pp.1-4.
https://search.emarefa.net/detail/BIM-1148131
American Medical Association (AMA)
AlQahtani, Hajar& Baloch, Saeed& Tabb, Deanne. Treatment of Recurrent Clostridium difficile Infection in an Immunocompromised Patient with Severe Neutropenia Not Responding to Standard Therapy. Case Reports in Infectious Diseases. 2020. Vol. 2020, no. 2020, pp.1-4.
https://search.emarefa.net/detail/BIM-1148131
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1148131