Antioxidant, Hypoglycemic, and Neurobehavioral Effects of a Leaf Extract of Avicennia marina on Autoimmune Diabetic Mice
Joint Authors
Abdel-Maksoud, Mostafa A.
Ajarem, Jamaan S.
Alatar, Abdulrahman
Okla, Mohammad K.
Alamri, Saud A.
Hegazy, Ahmed K.
Al-Ghamdi, Abdullah A.
Faisal, Mohammad
Abdel-Salam, Eslam M.
Ali, Hayssam M.
Salem, Mohamed Z. M.
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-05-21
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Diabetes mellitus (DM) is a metabolic disease that can affect the central nervous system and behavioral traits in animals.
Streptozotocin-induced diabetes is considered an autoimmune disease.
The aim of the current study was to determine whether supplementation with the alcoholic extract of Avicennia marina leaves could improve diabetes-associated pathological changes.
The animals were divided into four groups: a control group (A), an A.
marina receiving nondiabetic group (B), a diabetic group (C), and a DM group orally supplemented with A.
marina alcoholic leaf extract (D).
The DM group of animals receiving the alcoholic extract of A.
marina leaves had reduced blood glucose levels, improved blood picture, and organ functions.
This group also showed improvement in locomotory behavior.
The results of this study showed that supplementation with the alcoholic extract of A.
marina leaves reduced oxidative stress and blood sugar levels, protected the liver, and improved the neurobehavioral changes associated with diabetes in mice.
Introducing alcoholic leaf extract of A.
marina to diabetic mice decreased inflammatory cells aggregation, vacuolation, and hemorrhage.
Additionally, a positive effect of the alcoholic leaf extract on the histopathological changes was observed in the testicular tissue of treated mice.
American Psychological Association (APA)
Okla, Mohammad K.& Alamri, Saud A.& Alatar, Abdulrahman& Hegazy, Ahmed K.& Al-Ghamdi, Abdullah A.& Ajarem, Jamaan S.…[et al.]. 2019. Antioxidant, Hypoglycemic, and Neurobehavioral Effects of a Leaf Extract of Avicennia marina on Autoimmune Diabetic Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1148462
Modern Language Association (MLA)
Okla, Mohammad K.…[et al.]. Antioxidant, Hypoglycemic, and Neurobehavioral Effects of a Leaf Extract of Avicennia marina on Autoimmune Diabetic Mice. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1148462
American Medical Association (AMA)
Okla, Mohammad K.& Alamri, Saud A.& Alatar, Abdulrahman& Hegazy, Ahmed K.& Al-Ghamdi, Abdullah A.& Ajarem, Jamaan S.…[et al.]. Antioxidant, Hypoglycemic, and Neurobehavioral Effects of a Leaf Extract of Avicennia marina on Autoimmune Diabetic Mice. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1148462
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1148462