Dynamic Analysis of Metabolic Response in Gastric Ulcer (GU) Rats with Electroacupuncture Treatment Using 1H NMR-Based Metabolomics
Joint Authors
Shen, Jia-cheng
Lian, Lin-yu
Zhang, Yuan
He, Qi-da
Chen, Jiao-long
Zhang, Long-bin
Huang, Miao-sen
Liu, Mi
Qian, Lin-chao
Liu, Cai-chun
Yang, Zhongbao
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-04-22
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Gastric ulcer (GU), a common digestive disease, has a high incidence and seriously endangers health of human.
According to the previous studies, it has been proved that electroacupuncture at acupoints of stomach meridian had a good effect on GU.
However, there are few published studies on metabolic response in gastric ulcer (GU) rats with electroacupuncture treatment.
Herein, we observed the metabolic profiles in biological samples (stomach, liver, and kidney) of GU rats with electroacupuncture treatment by 1H NMR metabolomics combined with pathological examination.
The male SD rats were induced by intragastric administration of 70% ethanol after fasting for 24 hours and treated by electroacupuncture at Zusanli (ST36) and Liangmen (ST21) for 1 day, 4 days, or 7 days, respectively.
And the conventional histopathological examinations as well as metabolic pathways assays were also performed.
We found that GU rats were basically cured after electroacupuncture treatment for 4 days and had a complete recovery after electroacupuncture treatment for 7 days by being modulated comprehensive metabolic changes, involved in the function of neurotransmitters, energy metabolism, cells metabolism, antioxidation, tissue repairing, and other metabolic pathways.
These findings may be helpful to facilitate the mechanism elucidating of electroacupuncture treatment on GU.
American Psychological Association (APA)
Shen, Jia-cheng& Lian, Lin-yu& Zhang, Yuan& He, Qi-da& Chen, Jiao-long& Zhang, Long-bin…[et al.]. 2019. Dynamic Analysis of Metabolic Response in Gastric Ulcer (GU) Rats with Electroacupuncture Treatment Using 1H NMR-Based Metabolomics. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1148473
Modern Language Association (MLA)
Shen, Jia-cheng…[et al.]. Dynamic Analysis of Metabolic Response in Gastric Ulcer (GU) Rats with Electroacupuncture Treatment Using 1H NMR-Based Metabolomics. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-12.
https://search.emarefa.net/detail/BIM-1148473
American Medical Association (AMA)
Shen, Jia-cheng& Lian, Lin-yu& Zhang, Yuan& He, Qi-da& Chen, Jiao-long& Zhang, Long-bin…[et al.]. Dynamic Analysis of Metabolic Response in Gastric Ulcer (GU) Rats with Electroacupuncture Treatment Using 1H NMR-Based Metabolomics. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1148473
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1148473