Salvia miltiorrhiza Bunge (Danshen) for Treatment and Prevention of Urolithiasis: A Drosophila Animal Study
Joint Authors
Chen, Huey-Yi
Chen, Wen-Chi
Man, Kee-Ming
Chou, Tzu-Yang
Yang, You-Rong
Tsai, Ming-Yen
Chen, Yung-Hsiang
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-01-20
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Traditional Chinese medicine (TCM) has been prescribed for the treatment of stone disease for thousands of years.
Salvia miltiorrhiza (Danshen) was previously shown to have potential for treatment of stone disease in animal and clinical studies.
In this study, we further studied the antiurolithiasis effect of Danshen in a fly model.
Wild-type male Drosophila melanogaster CS flies were used in this study, with 0.25% ethylene glycol (EG) as a lithogenic agent.
2% potassium citrate (K-citrate) was the positive control agent for prevention (all agents added at the start of experiment) and treatment (drugs added after 2-week addition of lithogenic agent) studies compared with 15, 30, and 60 μg/ml of Danshen extract.
In the prevention study, both 2% K-citrate and Danshen (30 and 60 μg/ml) significantly inhibited EG-induced calcium oxalate (CaOx) crystal formation.
In the treatment study, only 2% K-citrate and high-dose of Danshen (60 μg/ml) significantly inhibited EG-induced CaOx crystal formation.
Survival analysis for EG with Danshen was compared with that for EG with K-citrate.
The mean lifespan was significantly reduced by administration of EG, and the results in the Danshen group were similar to those in the control group.
In conclusion, Danshen revealed both preventive and treatment effects on CaOx crystal formation in a fly model.
American Psychological Association (APA)
Chen, Wen-Chi& Chou, Tzu-Yang& Chen, Huey-Yi& Yang, You-Rong& Man, Kee-Ming& Tsai, Ming-Yen…[et al.]. 2019. Salvia miltiorrhiza Bunge (Danshen) for Treatment and Prevention of Urolithiasis: A Drosophila Animal Study. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-5.
https://search.emarefa.net/detail/BIM-1148546
Modern Language Association (MLA)
Chen, Wen-Chi…[et al.]. Salvia miltiorrhiza Bunge (Danshen) for Treatment and Prevention of Urolithiasis: A Drosophila Animal Study. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-5.
https://search.emarefa.net/detail/BIM-1148546
American Medical Association (AMA)
Chen, Wen-Chi& Chou, Tzu-Yang& Chen, Huey-Yi& Yang, You-Rong& Man, Kee-Ming& Tsai, Ming-Yen…[et al.]. Salvia miltiorrhiza Bunge (Danshen) for Treatment and Prevention of Urolithiasis: A Drosophila Animal Study. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-5.
https://search.emarefa.net/detail/BIM-1148546
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1148546