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Late Onset Cobalamin Disorder and Hemolytic Uremic Syndrome: A Rare Cause of Nephrotic Syndrome
Joint Authors
Ardissino, Gianluigi
Perrone, Michela
Tel, Francesca
Testa, Sara
Morrone, Amelia
Possenti, Ilaria
Tagliaferri, Francesco
Dilena, Robertino
Menni, Francesca
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-08-01
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Hemolytic uremic syndrome (HUS) is an unrare and severe thrombotic microangiopathy (TMA) caused by several pathogenetic mechanisms among which Shiga toxin-producing Escherichia coli infections and complement dysregulation are the most common.
However, very rarely and particularly in neonates and infants, disorders of cobalamin metabolism (CblC) can present with or be complicated by TMA.
Herein we describe a case of atypical HUS (aHUS) related to CblC disease which first presented in a previously healthy boy at age of 13.6 years.
The clinical picture was initially dominated by nephrotic range proteinuria and severe hypertension followed by renal failure.
The specific treatment with high dose of hydroxycobalamin rapidly obtained the remission of TMA and the complete recovery of renal function.
We conclude that plasma homocysteine and methionine determinations together with urine organic acid analysis should be included in the diagnostic work-up of any patient with TMA and/or nephrotic syndrome regardless of age.
American Psychological Association (APA)
Ardissino, Gianluigi& Perrone, Michela& Tel, Francesca& Testa, Sara& Morrone, Amelia& Possenti, Ilaria…[et al.]. 2017. Late Onset Cobalamin Disorder and Hemolytic Uremic Syndrome: A Rare Cause of Nephrotic Syndrome. Case Reports in Pediatrics،Vol. 2017, no. 2017, pp.1-4.
https://search.emarefa.net/detail/BIM-1149269
Modern Language Association (MLA)
Ardissino, Gianluigi…[et al.]. Late Onset Cobalamin Disorder and Hemolytic Uremic Syndrome: A Rare Cause of Nephrotic Syndrome. Case Reports in Pediatrics No. 2017 (2017), pp.1-4.
https://search.emarefa.net/detail/BIM-1149269
American Medical Association (AMA)
Ardissino, Gianluigi& Perrone, Michela& Tel, Francesca& Testa, Sara& Morrone, Amelia& Possenti, Ilaria…[et al.]. Late Onset Cobalamin Disorder and Hemolytic Uremic Syndrome: A Rare Cause of Nephrotic Syndrome. Case Reports in Pediatrics. 2017. Vol. 2017, no. 2017, pp.1-4.
https://search.emarefa.net/detail/BIM-1149269
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1149269