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Corneal Perforation during Combination Chemotherapy including Cetuximab in a Patient with a History of Herpetic Keratitis
Joint Authors
Kusaka, Shunji
Kodama-Takahashi, Aya
Aomatsu, Keiichi
Fukuda, Masahiko
Sugioka, Koji
Mishima, Hiroshi
Source
Case Reports in Oncological Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-07-08
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Purpose.
To report a case of corneal perforation, in a patient with a history of herpetic keratitis, during combination chemotherapy including cetuximab.
Case.
We report the case of a 71-year-old man who was diagnosed with a hypopharyngeal carcinoma and received radiation therapy combined with cetuximab, the epidermal growth factor receptor (EGFR) inhibitor monoclonal antibody.
He was referred to us because of ocular hyperemia and corneal perforation in his left eye.
In spite of conservative therapy, his corneal perforation was exacerbated, with iris incarceration into the wound site and exposure to the surface of the cornea.
He therefore discontinued treatment with the combination chemotherapy and underwent lamellar keratoplasty using a preserved donor cornea.
After treatment with cetuximab resumed, there was no recurrence of the corneal perforation.
Conclusion.
We have presented the first case of cetuximab-related corneal perforation in a patient who had a history of recurrent herpetic keratitis.
EGFR inhibitors, such as cetuximab, can induce corneal perforation in cases with a history of herpetic stromal keratitis.
American Psychological Association (APA)
Aomatsu, Keiichi& Sugioka, Koji& Kodama-Takahashi, Aya& Fukuda, Masahiko& Mishima, Hiroshi& Kusaka, Shunji. 2020. Corneal Perforation during Combination Chemotherapy including Cetuximab in a Patient with a History of Herpetic Keratitis. Case Reports in Oncological Medicine،Vol. 2020, no. 2020, pp.1-4.
https://search.emarefa.net/detail/BIM-1149439
Modern Language Association (MLA)
Aomatsu, Keiichi…[et al.]. Corneal Perforation during Combination Chemotherapy including Cetuximab in a Patient with a History of Herpetic Keratitis. Case Reports in Oncological Medicine No. 2020 (2020), pp.1-4.
https://search.emarefa.net/detail/BIM-1149439
American Medical Association (AMA)
Aomatsu, Keiichi& Sugioka, Koji& Kodama-Takahashi, Aya& Fukuda, Masahiko& Mishima, Hiroshi& Kusaka, Shunji. Corneal Perforation during Combination Chemotherapy including Cetuximab in a Patient with a History of Herpetic Keratitis. Case Reports in Oncological Medicine. 2020. Vol. 2020, no. 2020, pp.1-4.
https://search.emarefa.net/detail/BIM-1149439
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1149439