Galactomannan in Bronchoalveolar Lavage Fluid for Diagnosis of Invasive Pulmonary Aspergillosis with Nonneutropenic Patients
Joint Authors
Ma, Hongying
Zhuang, Qidong
Zhang, Yun
Chen, Lei
Wang, Li
Zheng, Lin
Deng, Zaichun
Chen, Zhongbo
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-11-13
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
We evaluated the utility of galactomannan (GM) in bronchoalveolar lavage fluid (BALF) for the diagnosis of invasive pulmonary aspergillosis (IPA) in nonneutropenic patients.
Methods.
A total of 183 patients were included in the final analysis.
Bronchoscopies and the detection of GM in BALF were all performed on them.
Results.
Ten cases of IPA were diagnosed.
ROC data demonstrated that, for diagnosing IPA, an optimal cutoff value for GM in BALF of 0.76 yielded a sensitivity of 100.0% and a specificity of 76.2%.
Symptoms and radiological findings had no significant difference between proven or probable IPA group and non-IPA group.
In our case-control analysis, although nine patients with false-positive results received treatment with Piperacillin/tazobactam, there was no significant difference between case and control group.
Conclusions.
BALF GM detection is a valuable adjunctive diagnostic tool.
Our retrospective study suggests that the optimal value of GM detection in BALF is 0.76 in nonneutropenic patients.
American Psychological Association (APA)
Zhuang, Qidong& Ma, Hongying& Zhang, Yun& Chen, Lei& Wang, Li& Zheng, Lin…[et al.]. 2017. Galactomannan in Bronchoalveolar Lavage Fluid for Diagnosis of Invasive Pulmonary Aspergillosis with Nonneutropenic Patients. Canadian Respiratory Journal،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1150812
Modern Language Association (MLA)
Zhuang, Qidong…[et al.]. Galactomannan in Bronchoalveolar Lavage Fluid for Diagnosis of Invasive Pulmonary Aspergillosis with Nonneutropenic Patients. Canadian Respiratory Journal No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1150812
American Medical Association (AMA)
Zhuang, Qidong& Ma, Hongying& Zhang, Yun& Chen, Lei& Wang, Li& Zheng, Lin…[et al.]. Galactomannan in Bronchoalveolar Lavage Fluid for Diagnosis of Invasive Pulmonary Aspergillosis with Nonneutropenic Patients. Canadian Respiratory Journal. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1150812
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1150812