Investigation of Safety Profile of Four Copaifera Species and of Kaurenoic Acid by SalmonellaMicrosome Test
Joint Authors
Bastos, Jairo Kennup
Martins, C. H. G.
Resende, Flávia Aparecida
Ambrosio, Sergio R.
Damasceno, Jaqueline L.
Arnet, Yadira Fernández
Fortunato, Giovanna Capaldi
Girotto, Luiza
Marena, Gabriel Davi
Rocha, Beatriz Patti
Veneziani, Rodrigo Cássio Sola
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-01-10
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Trees of the Copaifera genus are native to the tropical regions of Latin America and Western Africa.
Copaifera sp is widely used as a popular medicine and it has various ethnopharmacological indications, including gonorrhea, bronchitis, asthma, skin ulcers, ulcers, sore throat, uterine infections, general inflammations, cancer, and leishmanioses.
Kaurenoic acid is a naturally occurring diterpene found in Copaifera and has been used as an anti-inflammatory, treatment of ulcer, leishmaniasis, and cancer.
Bearing in mind the fact that the Ames test is an excellent tool to assess the safety of extracts, oils, and phytochemicals isolated from medicinal plants, from it, we evaluate the mutagenic potential of four species, between oleoresins (C.
oblongifolia; C.
langsdorffii) and leaves extracts (C.
lucens; C.
multijuga), of the Copaifera genus and also of kaurenoic acid, which is one of its major compounds.
The results showed that the Copaifera spp.
and kaurenoic acid did not induce an increase in the number of revertant colonies, without mutagenic effect in experiments, in the all concentrations evaluated by Ames test.
The results obtained in our study support the safe use of the Copaifera genus medicinal plants selected and of kaurenoic acid.
American Psychological Association (APA)
Damasceno, Jaqueline L.& Arnet, Yadira Fernández& Fortunato, Giovanna Capaldi& Girotto, Luiza& Marena, Gabriel Davi& Rocha, Beatriz Patti…[et al.]. 2019. Investigation of Safety Profile of Four Copaifera Species and of Kaurenoic Acid by SalmonellaMicrosome Test. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1151032
Modern Language Association (MLA)
Damasceno, Jaqueline L.…[et al.]. Investigation of Safety Profile of Four Copaifera Species and of Kaurenoic Acid by SalmonellaMicrosome Test. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1151032
American Medical Association (AMA)
Damasceno, Jaqueline L.& Arnet, Yadira Fernández& Fortunato, Giovanna Capaldi& Girotto, Luiza& Marena, Gabriel Davi& Rocha, Beatriz Patti…[et al.]. Investigation of Safety Profile of Four Copaifera Species and of Kaurenoic Acid by SalmonellaMicrosome Test. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1151032
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1151032