Effect of Polysaccharides from Bletilla striata on the Healing of Dermal Wounds in Mice
Joint Authors
Zhang, Chen
He, Yanan
Chen, Zhejie
Shi, Jinfeng
Qu, Yan
Zhang, Jinming
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-10-24
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Bletilla striata has been largely used in traditional folk medicine in China as a wound healing agent and to treat gastritis and several other health problems.
Some studies have shown that plant polysaccharides may have the ability to promote wound healing.
The aim of this work was to evaluate the wound healing activity of the polysaccharide extracted from Bletilla striata.
Firstly, a Bletilla striata polysaccharide was extracted by water extraction and alcohol precipitation and characterized by Fourier transform infrared spectroscopy.
The Bletilla striata polysaccharide was then tested for cell migration and proliferation using the mouse fibroblast cell line.
Then, the Bletilla striata hydrogel was fabricated for acute wound health care of the mouse full-thickness excision.
The results showed that the BSP enhanced the proliferation and migration of L929 cells.
The superior wound healing capacity of the BSP hydrogel was demonstrated that it significantly accelerated the wound healing process in vivo in full-thickness skin defect wounded models.
Compared to the saline group, the BSP hydrogel could accelerate wound healing and promote re-epithelialization and collagen deposition by means of TGF-β/Smad signal pathway activation.
Taken together, BSP hydrogel would be a useful pharmaceutic candidate for acute cutaneous wound health care.
American Psychological Association (APA)
Zhang, Chen& He, Yanan& Chen, Zhejie& Shi, Jinfeng& Qu, Yan& Zhang, Jinming. 2019. Effect of Polysaccharides from Bletilla striata on the Healing of Dermal Wounds in Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1151618
Modern Language Association (MLA)
Zhang, Chen…[et al.]. Effect of Polysaccharides from Bletilla striata on the Healing of Dermal Wounds in Mice. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1151618
American Medical Association (AMA)
Zhang, Chen& He, Yanan& Chen, Zhejie& Shi, Jinfeng& Qu, Yan& Zhang, Jinming. Effect of Polysaccharides from Bletilla striata on the Healing of Dermal Wounds in Mice. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1151618
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1151618