Effects of Moxibustion and Moxa Smoke on Behavior Changes and Energy Metabolism in APPPS1 Mice
Joint Authors
Yan, Zhi-Yi
Ha, Lue
Yu, Mengyun
Rui, Zhang
Zhao, Baixiao
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-08-14
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Objective.
To investigate the antiaging effects of moxibustion and moxa smoke on APP/PS1 mice and to illustrate the mechanism of moxibustion improving Alzheimer’s disease (AD).
Methods.
36 male APP/PS1 mice were randomly assigned into three groups (n = 12), including a model control group, a moxibustion group, and a moxa smoke group.
In addition, 12 C57BL/6 normal mice served as a normal (negative) control group.
Mice in the moxibustion group received moxibustion intervention using Guanyuan (RN4) acupoint.
Mice in the moxa smoke group received moxa smoke exposure with the same frequency as the moxibustion group.
Behavioral tests were implemented in the 9th week, 3 days after the completion of the intervention.
Tricarboxylic acid cycle and fatty acid metabolomics assessments of the mice were determined after behavioral tests.
Results.
In this study, relative to normal mice, we found that AD mice showed altered tricarboxylic and fatty acid metabolism and showed behavioral changes consistent with the onset of AD.
However, both the moxibustion and moxa smoke interventions were able to mitigate these effects to some degree in AD mice.
Conclusions.
The data suggest that tricarboxylic acid cycle and unsaturated fatty acid metabolomics changes may be a target of AD, and the beneficial effects of moxibustion on cognitive behaviors may be mediated by the energy metabolism system.
American Psychological Association (APA)
Ha, Lue& Yu, Mengyun& Yan, Zhi-Yi& Rui, Zhang& Zhao, Baixiao. 2019. Effects of Moxibustion and Moxa Smoke on Behavior Changes and Energy Metabolism in APPPS1 Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1151708
Modern Language Association (MLA)
Ha, Lue…[et al.]. Effects of Moxibustion and Moxa Smoke on Behavior Changes and Energy Metabolism in APPPS1 Mice. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1151708
American Medical Association (AMA)
Ha, Lue& Yu, Mengyun& Yan, Zhi-Yi& Rui, Zhang& Zhao, Baixiao. Effects of Moxibustion and Moxa Smoke on Behavior Changes and Energy Metabolism in APPPS1 Mice. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1151708
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1151708