Overexpression of miR-24 Is Involved in the Formation of Hypocoagulation State after Severe Trauma by Inhibiting the Synthesis of Coagulation Factor X
Joint Authors
Chen, Lu-Jia
Yang, Lian
Cheng, Xing
Xue, Yin-Kai
Chen, Li-Bo
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-06-14
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
Dysregulation of microRNAs may contribute to the progression of trauma-induced coagulopathy (TIC).
We aimed to explore the biological function that miRNA-24-3p (miR-24) might have in coagulation factor deficiency after major trauma and TIC.
Methods.
15 healthy volunteers and 36 severe trauma patients (Injury Severity Score ≥ 16 were enrolled.
TIC was determined as the initial international normalized ratio >1.5.
The miR-24 expression and concentrations of factor X (FX) and factor XII in plasma were measured.
In vitro study was conducted on L02 cell line.
Results.
The plasma miR-24 expression was significantly elevated by 3.17-fold (P=0.043) in major trauma patients and reduced after 3 days (P<0.01).
The expression level was significantly higher in TIC than in non-TIC patients (P=0.040).
Multivariate analysis showed that the higher miR-24 expression was associated with TIC.
The plasma concentration of FX in TIC patients was significantly lower than in the non-TIC ones (P=0.030) and controls (P<0.01).
A negative correlation was observed between miR-24 and FX.
miR-24 transduction significantly reduced the FX level in the supernatant of L02 cells (P=0.030).
Conclusions.
miR-24 was overexpressed in major trauma and TIC patients.
The negative correlation of miR-24 with FX suggested the possibility that miR-24 might inhibit the synthesis of FX during TIC.
American Psychological Association (APA)
Chen, Lu-Jia& Yang, Lian& Cheng, Xing& Xue, Yin-Kai& Chen, Li-Bo. 2017. Overexpression of miR-24 Is Involved in the Formation of Hypocoagulation State after Severe Trauma by Inhibiting the Synthesis of Coagulation Factor X. Disease Markers،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1152296
Modern Language Association (MLA)
Chen, Lu-Jia…[et al.]. Overexpression of miR-24 Is Involved in the Formation of Hypocoagulation State after Severe Trauma by Inhibiting the Synthesis of Coagulation Factor X. Disease Markers No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1152296
American Medical Association (AMA)
Chen, Lu-Jia& Yang, Lian& Cheng, Xing& Xue, Yin-Kai& Chen, Li-Bo. Overexpression of miR-24 Is Involved in the Formation of Hypocoagulation State after Severe Trauma by Inhibiting the Synthesis of Coagulation Factor X. Disease Markers. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1152296
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1152296