A Predictive Model for Super-Response to Cardiac Resynchronization Therapy: The QQ-LAE Score
Joint Authors
Zhang, Shu
Hua, Wei
Hu, Yiran
Niu, Hongxia
Gu, Min
Liu, Xi
Yang, Shengwen
Ding, Li-Gang
Wang, Jing
Source
Cardiology Research and Practice
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-08-28
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Objectives.
It is important to identify super-responders who can derive most benefits from cardiac resynchronization therapy (CRT).
We aimed to establish a scoring model that can be used for predicting super-response to CRT.
Methods.
We retrospectively reviewed 387 CRT patients.
Multivariate logistic regression analysis was performed to identify predictors for super-response (defined as an absolute increase in left ventricular ejection fraction of ≥15% at 6-month follow-up) and to create a score model.
Multivariate Cox proportional-hazard regression analysis was conducted to assess associations with the long-term endpoint (defined as cardiac death/heart transplant, heart failure (HF) hospitalization, or all-cause death) across the score categories at follow-up.
Results.
Among 387 patients, 109 (28.2%) met super-response.
In multivariable analysis, 5 independent predictors (QQ-LAE) were identified: prior no fragmented QRS (odds ratio (OR) = 3.10 (1.39, 6.94)), QRS duration ≥170 ms (OR = 2.37 (1.35, 4.12)), left bundle branch block (OR = 2.57 (1.04, 6.37)), left atrial diameter <45 mm (OR = 3.27 (1.81, 5.89)), and left ventricular end-diastolic dimension <75 mm (OR = 4.11 (1.99, 8.48)).
One point was attributed to each predictor, and three score categories were identified.
The proportion of super-response after 6-month CRT implantation in patients with scores 0–3, 4, and 5 was 14.6%, 40.3%, and 64.1%, respectively (P<0.001).
Patients with score 5 had an 88% reduction in the risk of cardiac death/heart transplant (P=0.042), a 71% reduction in the risk of HF hospitalization (P=0.048), and an 89% reduction in the risk of all-cause mortality (P=0.028) compared to patients with scores 0–3.
Conclusions.
The QQ-LAE score can be used for prediction of super-response to CRT and selection of most suitable patients in clinical practices.
American Psychological Association (APA)
Liu, Xi& Hu, Yiran& Hua, Wei& Yang, Shengwen& Gu, Min& Niu, Hongxia…[et al.]. 2020. A Predictive Model for Super-Response to Cardiac Resynchronization Therapy: The QQ-LAE Score. Cardiology Research and Practice،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1152421
Modern Language Association (MLA)
Liu, Xi…[et al.]. A Predictive Model for Super-Response to Cardiac Resynchronization Therapy: The QQ-LAE Score. Cardiology Research and Practice No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1152421
American Medical Association (AMA)
Liu, Xi& Hu, Yiran& Hua, Wei& Yang, Shengwen& Gu, Min& Niu, Hongxia…[et al.]. A Predictive Model for Super-Response to Cardiac Resynchronization Therapy: The QQ-LAE Score. Cardiology Research and Practice. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1152421
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1152421